Sulfamethylthiazole

from Wikipedia, the free encyclopedia
Structural formula
Structural formula of Neodiseptal
General
Non-proprietary name Sulfamethylthiazole
other names
  • 4-Amino- N - (4-methyl-1,3-thiazol-2-yl) benzene sulfonamide ( IUPAC )
  • Aseptile 2
  • Ciba 3753
  • M. and B. 838
  • N - (4-methyl-2-thiazolyl) sulfanilamide
  • Novoseptal
  • RP 146
  • Staphylamide
  • Neodiseptal
  • Sulfazole
  • Toriseptin M.
  • Ultraseptal
  • Ultraseptyl
Molecular formula C 10 H 11 N 3 O 2 S 2
External identifiers / databases
CAS number
EC number 208-203-8
ECHA InfoCard 100.007.459
PubChem 68194
ChemSpider 61501
Wikidata Q1684286
Drug information
Drug class

Sulfonamide

properties
Molar mass 269.36 g mol −1
Physical state

firmly

Melting point

238-240 ° C

solubility

little in water (0.2 g in 100 ml), slightly in alkaline solutions or diluted mineral acids

safety instructions
GHS labeling of hazardous substances
07 - Warning

Caution

H and P phrases H: 315-319-335
P: ?
Toxicological data

27,670 mg kg −1 ( LD 50 ,  mouse ,  oral )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Sulfamethylthiazole is an antibacterial agent belonging to the sulfonamide class . It is the monomethyl derivative of sulfathiazole .

history

Sulfamethylthiazole was manufactured under the name Ultraseptyl during the National Socialist era by the Chinoin Works ( Budapest ), in which Hitler's personal physician Theo Morell was financially involved. Morell also gave Hitler himself Ultraseptyl, although there were serious side effects.

Individual evidence

  1. ↑ a b data sheet at Druglead.com (accessed July 5, 2010).
  2. ↑ Template: CL Inventory / not harmonized There is not yet a harmonized classification for this substance . A labeling of N'1- (4-methylthiazol-2-yl) sulphanilamide Template: link text check / apostrophe in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), retrieved on July 19, 2019, is reproduced from a self-classification by the distributor .
  3. ↑ MSDS at ChemCAS.com (accessed July 5, 2010).
  4. ↑ Notes on an Interview of Prof Dr Dr Ernst-Günther Schenck at Klagenfurt, Austria, May 11-12, 1982 (tape-recorded) (accessed on July 5, 2010).
  5. ↑ David Irving: Hitler's War, Ch. 39 (accessed July 5, 2010).