Sulfathiazole

Structural formula
General
Non-proprietary name	Sulfathiazole
other names	Thiazamide; Sulzol; 4-Amino- N - (1,3-thiazol-2-yl) benzenesulfonamide ( IUPAC );
Molecular formula	C 9 H 9 N 3 O 2 S 2
Brief description	White to slightly yellowish, crystalline powder
External identifiers / databases
EC number	200-771-5
ECHA InfoCard	100,000,701
PubChem	5340
ChemSpider	5148
DrugBank	DB06147
Wikidata	Q408427
Drug information
ATC code	Q D06BA02 ; Q J01EQ07 ; Q J01EW30 ;
Drug class	Antibiotic ( sulfonamide )
properties
Molar mass	255.32 g mol −1
Physical state	firmly
Melting point	200-203 ° C
solubility	Water: practically insoluble; Ethanol 96%: hardly soluble; Dichloromethane: practically insoluble; Diluted mineral acids and diluted alkali hydroxides: Soluble;
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances Caution
H and P phrases	H: 315-319-335
	P: 261-305 + 351 + 338
Toxicological data	990 mg kg −1 ( LD 50 , mouse , iv ) ; 4500 mg kg −1 ( LD 50 , mouse , oral ) ; 1370 mg kg −1 ( LD 50 , rat , iv ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Sulfathiazole (STZ) is an antibiotic from the sulfonamide class of active ingredients . It is used, among other things, in animal breeding and beekeeping (against American foulbrood ); according to EU regulation, its use in this area is no longer permitted, as resistance has already occurred several times (outside the EU, sometimes still legal). In veterinary medicine outside of the areas mentioned, it is still permitted.

In human medicine, the active ingredient is used, for example in combination with corticoids , in preparations for the treatment of infectious inflammatory conditions of the skin.

Sulfathiazole pure: a pale yellowish, crystalline powder; a white piece of paper for comparison

Trade names

Combination preparations

Sulfathiazole in combination with sulfadimidine and trimethoprim : Vetoprim 24% ad us. vet. (D, CH), B-TS Trio ad us. vet. (CH)

Culture

Sulfathiazole appears in various literary works of the modern age, for example in Kurt Vonnegut's novel Katzenwiege and in various of his short stories. In Otto Preminger's film Exodus , the American nurse Kitty Fremont tells Dr. Odenheimer that sulfathiazole can be used as a remedy for impetigo contagiosa . In John Irving's fourth novel, Garp and How He Saw the World , sulfathiazole appears in the first chapter when Garp's mother sees it being distributed to soldiers of World War II .

Individual evidence

↑ ^a ^b ^c ^d ^e European Pharmacopoeia 6.2
↑ data sheet sulfathiazole at AlfaAesar, accessed on December 15, 2010 ( PDF )(JavaScript required) .
↑ ^a ^b data sheet sulfathiazoles from Sigma-Aldrich , accessed on November 4, 2016 ( PDF ).
^ ^A ^b ^c Axel Kleemann , Jürgen Engel, Bernd Kutscher and Dieter Reichert: Pharmaceutical Substances , 4th edition (2000) 2 volumes published by Thieme-Verlag Stuttgart, ISBN 978-1-58890-031-9 ; online since 2003 with biannual additions and updates.

Web links

Entry on sulfathiazole at Vetpharm, accessed on July 29, 2012.

[EAB-1] European Pharmacopoeia 6.2

[Alfa-2] ta sheet sulfathiazole at AlfaAesar, accessed on December 15, 2010 ( PDF )(JavaScript required) .

[Sigma-3] ta sheet sulfathiazoles from Sigma-Aldrich , accessed on November 4, 2016 ( PDF ).

[Kleemann-4] A ^b ^c Axel Kleemann , Jürgen Engel, Bernd Kutscher and Dieter Reichert: Pharmaceutical Substances , 4th edition (2000) 2 volumes published by Thieme-Verlag Stuttgart, ISBN 978-1-58890-031-9 ; online since 2003 with biannual additions and updates.