Valaciclovir
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Non-proprietary name | Valaciclovir | |||||||||||||||||||||
other names |
( S ) -2 - [(2-Amino-6-oxo-3,9-dihydropurin-9-yl) methoxy] ethyl 2-amino-3-methyl-butanoate |
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Molecular formula | C 13 H 20 N 6 O 4 | |||||||||||||||||||||
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Molar mass | 324.34 g mol −1 | |||||||||||||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Valaciclovir is an analogue of the nucleobase guanine . It is used as an antiviral agent in diseases with the varicella zoster virus (for example, in severe or generalized herpes zoster ) and with herpes simplex viruses .
pharmacology
Valaciclovir is a so-called prodrug of acyclovir and is converted into it in the body. Advantages of valaciclovir are faster absorption from the intestine and higher bioavailability (around 55% compared to 10%). Effects and side effects are the same as for acyclovir.
Stereoisomerism
Valaciclovir is chiral . Only the ( S ) enantiomer is used as a medicinal substance . Valaciclovir is an ester of the proteinogenic amino acid L - valine .
Trade names
Valaciclomed (A), Valdacir (A), Valtrex (D, A, CH), Viropel (A), numerous generics (A, CH)
Individual evidence
- ↑ a b Data sheet Valacyclovir hydrochloride hydrate from Sigma-Aldrich , accessed on April 25, 2011 ( PDF ).