Valnemulin
Structural formula | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
![]() |
|||||||||||||
General | |||||||||||||
Non-proprietary name | Valnemulin | ||||||||||||
other names |
({2 - [(R) -2-Amino-3-methylbutyramido] -1,1-dimethylethyl} thio) acetic acid- (3a S , 4 R , 5 S , 6 S , 8 R , 9 R , 9a R , 10 R ) -5,8-dihydroxy-4,6,9,10-tetramethyl-1-oxo-3a, 9-propano-6-vinyl-octahydro-3a H -cyclopentacycloocten-8-yl ester ( IUPAC ) |
||||||||||||
Molecular formula | C 31 H 52 N 2 O 5 S | ||||||||||||
External identifiers / databases | |||||||||||||
|
|||||||||||||
Drug information | |||||||||||||
ATC code | |||||||||||||
Drug class | |||||||||||||
Mechanism of action |
Elongation phase inhibition |
||||||||||||
properties | |||||||||||||
Molar mass | 564.82 g · mol -1 | ||||||||||||
Physical state |
solid (hydrochloride) |
||||||||||||
safety instructions | |||||||||||||
|
|||||||||||||
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Valnemulin is a is an antibiotically effective drug from the group of pleuromutilins . It is approved in the EU for veterinary medicine as Econor for the treatment of certain infectious diseases in pigs ( pig dysentery , porcine proliferative enteritis and enzootic pneumonia ) and rabbits.
properties
Valnemulin is a semi-synthetically produced substance. Valnemulin hydrochloride is used medicinally and is administered with feed .
Valnemulin is an antibiotic from the pleuromutilin group. This group of natural substances originating from mushrooms ( Clitopilus passeckerianus , "cat ear rasp ") was discovered in the 1950s. In addition to valnemulin, tiamulin , which is also used in veterinary medicine, and the drugs lefamulin and retapamulin used in human medicine are derived from the lead substance pleuromutilin .
The effect is based on the inhibition of bacterial protein synthesis by binding valnemulin to the bacterial ribosome .
Spectrum of activity
Valnemulin is effective against a variety of bacteria, including those causing intestinal and respiratory diseases in pigs. It is particularly effective against mycoplasmas and spirochetes such as Brachyspira hyodysenteriae and Brachyspira pilosicoli . Valnemulin is weakly effective against enterobacteria such as Salmonella and Escherichia coli . It is also effective against Lawsonia intracellularis .
In rabbits, valnemulin is able to reduce mortality in the event of an outbreak of rabbit epizootic enteropathy (ERE).
Trade names
Econor (EU)
Individual evidence
- ↑ a b c Data sheet Valnemulin hydrochloride, European Pharmacopoeia (EP) Reference Standard from Sigma-Aldrich , accessed on November 5, 2019 ( PDF ).
- ↑ External identifiers or database links for valnemulin hydrochloride : CAS number: 133868-46-9, EC number: 685-606-9, ECHA InfoCard: 100.211.221 , PubChem : 60195218 , ChemSpider : 29272183 , Wikidata : Q27292189 .
- ↑ "Valnemulin hydrochloride for animals": white to yellowish, amorphous, hygroscopic powder; Easily soluble in water and anhydrous ethanol , practically insoluble in tert -butyl methyl ether (European Pharmacopoeia, 8th edition, Grundwerk 2014, p. 5189 f.)
-
↑ Econor (Valnemulin) - overview of Econor and reasons for approval in the EU (PDF), 85 kB. See also:
Econor - Public European assessment report of the EMA , accessed on 4 November 2019 (English).