Wolfgang Patsch

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Wolfgang Patsch (born August 10, 1946 in Wels ) is an Austrian internist , laboratory physician and university professor at the Institute for Pharmacology and Toxicology at the Paracelsus Medical Private University in Salzburg . He is known for his work in the fields of atherosclerosis and metabolic and neurodegenerative diseases .

Life

Wolfgang Patsch studied medicine from 1964 to 1971 at the University of Innsbruck and the Medical University of Vienna . Since 1964 he has been a member of the Catholic student association AV Austria Innsbruck in the ÖCV . In 1971 he received his doctorate in Innsbruck sub auspiciis . Further education abroad took place on biochemistry in 1978 at the University of Uppsala and on mutagenesis in 1985 in Washington DC Patsch began his professional career in 1971 as an assistant doctor for internal medicine at the University of Innsbruck and acquired a specialist in internal medicine in 1977. This was followed by a long stay in the USA, first from 1978 to 1982 at Washington University in St. Louis , where Patsch obtained his jus practicandi for the state of Missouri in 1982 . From 1982 to 1993, Patsch worked at Baylor College of Medicine in Houston. He was director of the Atherosclerosis Laboratory at Baylor College of Medicine and Houston Methodist Hospital from 1982 to 1993 . In 1985 Patsch received his habilitation from the University of Innsbruck. From 1985 to 1990 Patsch was a Research Associate Professor of Medicine at Baylor College of Medicine. There he was director of the CDC-Cholesterol Reference Laboratory from 1987 to 1993 and full professor of medicine in 1990. In 1987 Patsch acquired a specialist in internal medicine in the USA and in 1988 the jus practicandi in Texas. In 1993 Patsch returned to Austria to take on the position of the board of directors of the Institute for Medical-Chemical Laboratory Diagnostics, which he held until 2011. In 1998 he was appointed associate professor in Austria. From the beginning of the planning for the establishment of the Private Medical University of Salzburg from 2000, Patsch, as its co-founder, was significantly involved in project groups and planning committees, where he was Dean of Research from 2003 to 2006. In 2006 Patsch was appointed professor at the Paracelsus Medical Private University in Salzburg. Patsch has been a university professor at the Institute for Pharmacology and Toxicology since 2011. Patsch has led numerous science projects, including the National Institutes of Health (NIH), the American Heart Association, the Federal Ministry of Science and Research, Vienna, and the Austrian Science Fund FWF.

Scientific contribution

Patsch's initial scientific work focused on the characterization of human lipoproteins . Together with Josef Patsch, a detailed physical-chemical description of sub-fractions of lipoproteins with very low and high density was carried out. At Washington University in St. Louis, Patsch applied the methods of lipoprotein isolation developed in Innsbruck in numerous clinical studies. In collaboration with Gustav Schonfeld, perfused rat livers and cell cultures of rat hepatocytes were used there in order to investigate the effects of hormones and nutrients on lipoprotein biosynthesis. Studies on hepatic lipoprotein synthesis with Strobl and Soyal continued at Baylor College in Houston. In collaboration with Josef Patsch and Antonio M. Gotto, the predictive importance of postprandial lipemia for coronary heart disease was demonstrated. From 1985 to 1994 Patsch was one of the main people responsible for the Atherosclerosis Risk in Communities Study (ARIC), in which numerous risk factors for atherosclerosis were examined in excellently characterized populations. After returning to Austria, Patsch's scientific work in collaboration with H. Esterbauer, H. Oberkofler, T. Felder and F. Krempler focused on genetic and pathophysiological aspects of energy metabolism, which are relevant for obesity , type 2 diabetes and the metabolic Syndrome are relevant. Only recently, Soyal and Patsch discovered brain-specific isoforms of PGC-1alpha that play a pathophysiological role in neurodegenerative diseases such as Huntington's disease , amyotrophic lateral sclerosis and Parkinson's disease .

In addition to his research activities, Patsch also made contributions to scientific research as a reviewer for medical journals, as an organizer of congresses and as a committee member / reviewer for international institutions for science funding such as the NIH , NHLBI and NIDDK, Swiss National Fund for the Promotion of Scientific Research , the Israel Science Foundation , the Netherlands Genomic Initiative, the Dutch Ministry of Economic Affairs and the EU.

Membership in international scientific associations

Patsch is or was a member of numerous relevant national and international scientific associations

Patsch is a member of the advisory board or editorial committee of the following specialist journal:

  • Current Diabetes Reviews (since 2004)

honors and awards

  • 1971 PhD sub auspiciis of the President of Austria
  • 1974 Unilever Prize, Vienna
  • 1975/76/94 Hoechst Foundation, Innsbruck, Graz, and Vienna
  • 1979 Medical Association Prize, Tyrol and Vorarlberg
  • 1987 American Board of Internal Medicine, among the 2 percent best exam candidates
  • 1990/91/94 Austrian Prize of the Society for Pediatrics and Adolescent Medicine
  • 1999 Hans Wendt Prize from the Salzburg Medical Association
  • 1999 Prize of the Austrian Atherosclerosis Society
  • 2000 Prize of the Austrian Society for Laboratory Medicine and Clinical Chemistry
  • 2005 Among the 5% best NIH grant recipients between 1980 and 2004
  • 2012 Sanofi Prize, Austria

Publications

Web links

Individual evidence

  1. ↑ Complete directory of the ÖCV 2004, IV - 410.
  2. ↑ uibk.ac.at
  3. ↑ pmu.ac.at ( Memento from August 8, 2014 in the Internet Archive )
  4. ^ W. Patsch, JR Patsch, GM Kostner, S. Sailer, H. Braunsteiner: Isolation of subfractions of human very low density lipoproteins by zonal ultracentrifugation. In: J Biol Chem . 253, 1978, pp. 4911-4915.
  5. ↑ W. Patsch, G. Schonfeld, AM Gotto Jr, JR Patsch: Characterization of human high density lipoproteins by zonal ultracentrifugation. In: J Biol Chem. 255, 1980, pp. 3178-3185.
  6. ^ AP Goldberg, HR Harter, W. Patsch, KB Schechtman, M. Province, C. Weerts, I. Kuisk, MM McCrate, G. Schonfeld: Racial differences in plasma high density lipoproteins in patients receiving hemodialysis. In: N Engl J Med . 308, 1983, pp. 1245-1252.
  7. ^ W. Patsch, S. Franz, G. Schonfeld: Role of insulin in lipoprotein secretion by cultured rat hepatocytes. In: J Clin Invest. 71, 1983, pp. 1161-1174.
  8. ↑ W. Patsch, T. Tamai, G. Schonfeld: Effect of fatty acids on lipid and apoprotein secretion and association in hepatocyte cultures. In: J Clin Invest. 72, 1983, pp. 371-378.
  9. ↑ W. Strobl, N. Gorder, YC Lin-Lee, AM Gotto Jr., W. Patsch: Role of thyroid hormones in apolipoprotein AI gene expression in rat liver. In: J Clin Invest. 85, 1990, pp. 659-667.
  10. ↑ SM Soyal, C. Seelos, YC Lin-Lee, SR Sanders, AM Gotto Jr, DL Hachey, W. Patsch: Thyroid hormone influences the maturation of apolipoprotein AI messenger RNA in rat liver. In: J Biol Chem. 270, 1995, pp. 3996-4004.
  11. ↑ JR Patsch, S. Prasad, AM Gotto Jr, W. Patsch: High density lipoprotein2: relationship of the plasma levels of this lipoprotein species to its composition, to the magnitude of postprandial lipemia, and to the activities of lipoprotein lipase and hepatic lipase . In: J Clin Invest. 80, 1987, pp. 341-347.
  12. ↑ JR Patsch, G. Mies Bock, T. Hopferwieser, V. Muehlberger, E. Knapp, Dunn JK, AM Gotto Jr., W. Patsch: Relationship of triglyceride metabolism and coronary artery disease: Studies in the state postprandial. In: Arterioscler Thromb. 12, 1992, pp. 1336-1345.
  13. ↑ AA Nabulsi, AR Folsom, A. White, W. Patsch, G. Heiss, KK Wu, M. Szklo: Association of hormone replacement therapy with various cardiovascular risk factors in postmenopausal women. In: N Engl J Med. 328, 1993, pp. 1069-1075.
  14. ↑ AR Sharrett, CM Ballantyne, SA Coady, G. Heiss, PD Sorlie, D. Catellier, W. Patsch: Coronary heart disease prediction from lipoprotein cholesterol levels, triglycerides, lipoprotein (a), apolipoproteins AI and B, and HDL density subfractions : the Atherosclerosis Risk in Communities (ARIC) Study. In: Circulation . 104, 2001, pp. 1108-1113.
  15. ↑ H. Esterbauer, C. Schneitler, H. Oberkofler, C. Ebenbichler, B. Paulweber, F. Sandhofer, G. Ladurner, E. Hell, AD Strosberg, JR Patsch, F. Krempler, W. Patsch. A polymorphism in the UCP2 gene promoter is protective against obesity in middle-aged humans. In: Nature Genet . 28, 2001, pp. 178-183.
  16. ↑ H. Oberkofler, V. Linnemayr, R. Weitgasser, M. Xie, B. Iglseder, F. Krempler, B. Paulweber, W. Patsch: Complex haplotypes of the PGC-1 gene are associated with carbohydrate metabolism and type 2 diabetes mellitus. In: Diabetes 53, 2004, pp. 1385-1393.
  17. ↑ A. Jais, E. Einwallner, O. Sharif, TH Lu, SM Soyal, D. Neureiter, K. Dalgaard, K. Gossens, R. Martins, JC Duvigneau, S. Amann, J. Lindroos, H. Oberkofler, S. Saluzzo, S. Müller, K. Miller, F. Krempler, C. Hauser-Kronberger, M. Bilban, S. Knapp, CN Lumeng, W. Patsch, O. Wagner, JA Pospisilik, H. Esterbauer: Heme- oxygenase 1 drives metaflammation and insulin resistance in mouse and man. In: Cell . 158, 2014, pp. 25-40.
  18. ↑ SM Soyal, TK Felder, S. Auer, P. Hahne, H. Oberkofler, A. Witting, M. Paulmichl, GB Landwehrmeyer, P. Weydt, W. Patsch: A greatly extended PPARGC1A genomic locus encodes several new brain specific isoforms and influences Huntington Disease age-of-onset. In: Hum Mol Genet. 21, 2012, pp. 3461-3473.
  19. ↑ J. Eschbach, B. Schwalenstöcker, S. Soyal, D. Bayer Wiesner, C. Akimoto, AC Nilsson, A. Birve, T. Meyer, L. Dupuis, K. Danzer, PM Andersen, A. Witting, AC Ludolph , W. Patsch, P. Weydt: PGC-1 is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis. In: Hum Mol Genet. 22, 2013, pp. 3477-3484.
  20. ^ Editorial board of Current Diabetes Reviews
  21. ↑ abim.org
  22. ↑ salzburger-aerztegesellschaft.at
  23. ↑ aas.at
  24. ↑ oeglmkc.at
  25. ↑ pmu.ac.at
personal data
SURNAME Patsch, Wolfgang
BRIEF DESCRIPTION Austrian internist and laboratory doctor
DATE OF BIRTH August 10, 1946
PLACE OF BIRTH catfish