Human coronavirus 229E: Difference between revisions

From Wikipedia, the free encyclopedia
Browse history interactively
← Previous edit
Content deleted Content added
VisualWikitext
Add: pmc, doi, pages, issue, volume, journal, title, year, authors 1-11. | Use this tool. Report bugs. | #UCB_Gadget
Citation bot (talk | contribs)
Bots
4,907,426 edits
Alter: chapter. | Use this bot. Report bugs. | Suggested by Whoop whoop pull up | #UCB_webform 14/49
 
(4 intermediate revisions by 3 users not shown)
Line 10: Line 10:
}}
}}


'''''Human coronavirus 229E''''' ('''''HCoV-229E''''') is a species of [[coronavirus]] which infects humans and bats.<ref>{{Cite journal|last1=Lim|first1=Yvonne Xinyi|last2=Ng|first2=Yan Ling|last3=Tam|first3=James P.|last4=Liu|first4=Ding Xiang|date=2016-07-25|title=Human Coronaviruses: A Review of Virus–Host Interactions|journal=Diseases|volume=4|issue=3|pages=26|doi=10.3390/diseases4030026|issn=2079-9721|pmc=5456285|pmid=28933406|quote=See Table 1.|doi-access=free}}</ref> It is an [[Viral envelope|enveloped]], [[Sense (molecular biology)|positive-sense]], [[RNA|single-stranded]] [[RNA virus]] which enters its host cell by binding to the [[Alanine aminopeptidase|APN receptor]].<ref>{{cite book|vauthors=Fehr AR, Perlman S|title=Coronaviruses|date=2015|chapter=Coronaviruses: an overview of their replication and pathogenesis|series=Methods in Molecular Biology|publisher=Springer|volume=1282|pages=1–23|doi=10.1007/978-1-4939-2438-7_1|isbn=978-1-4939-2438-7|pmc=4369385|pmid=25720466|quote=See Table 1.|veditors=Maier HJ, Bickerton E, Britton P}}</ref> Along with [[Human coronavirus OC43]] (a member of the ''[[Betacoronavirus]]'' genus), it is one of the viruses responsible for the [[common cold]].<ref>{{cite journal | pmid = 21849456 | year = 2011 | last1 = Lau | first1 = S. K. | last2 = Lee | first2 = P. | last3 = Tsang | first3 = A. K. | last4 = Yip | first4 = C. C. | last5 = Tse | first5 = H. | last6 = Lee | first6 = R. A. | last7 = So | first7 = L. Y. | last8 = Lau | first8 = Y. L. | last9 = Chan | first9 = K. H. | last10 = Woo | first10 = P. C. | last11 = Yuen | first11 = K. Y. | title = Molecular epidemiology of human coronavirus OC43 reveals evolution of different genotypes over time and recent emergence of a novel genotype due to natural recombination | journal = Journal of Virology | volume = 85 | issue = 21 | pages = 11325–11337 | doi = 10.1128/JVI.05512-11 | pmc = 3194943 }}</ref><ref>{{cite journal | pmid = 20554810 | year = 2010 | last1 = Gaunt | first1 = E. R. | last2 = Hardie | first2 = A. | last3 = Claas | first3 = E. C. | last4 = Simmonds | first4 = P. | last5 = Templeton | first5 = K. E. | title = Epidemiology and clinical presentations of the four human coronaviruses 229E, HKU1, NL63, and OC43 detected over 3 years using a novel multiplex real-time PCR method | journal = Journal of Clinical Microbiology | volume = 48 | issue = 8 | pages = 2940–2947 | doi = 10.1128/JCM.00636-10 | pmc = 2916580 }}</ref> HCoV-229E is a member of the genus ''[[Alphacoronavirus]]'' and subgenus ''Duvinacovirus''.<ref name="ICTV10">{{cite web|url=https://talk.ictvonline.org/taxonomy/|title=Virus Taxonomy: 2018 Release|date=October 2018|website=International Committee on Taxonomy of Viruses (ICTV)|language=en|access-date=13 January 2019}}</ref><ref name=":02">{{Cite journal|last1=Woo|first1=Patrick C. Y.|last2=Huang|first2=Yi|last3=Lau|first3=Susanna K. P.|last4=Yuen|first4=Kwok-Yung|date=2010-08-24|title=Coronavirus Genomics and Bioinformatics Analysis|journal=Viruses|volume=2|issue=8|pages=1804–1820|doi=10.3390/v2081803|issn=1999-4915|pmc=3185738|pmid=21994708|quote=Figure 2. Phylogenetic analysis of RNA-dependent RNA polymerases (Pol) of coronaviruses with complete genome sequences available. The tree was constructed by the neighbor-joining method and rooted using Breda virus polyprotein.|doi-access=free}}</ref>
'''''Human coronavirus 229E''''' ('''''HCoV-229E''''') is a species of [[coronavirus]] which infects humans and bats.<ref>{{Cite journal|last1=Lim|first1=Yvonne Xinyi|last2=Ng|first2=Yan Ling|last3=Tam|first3=James P.|last4=Liu|first4=Ding Xiang|date=2016-07-25|title=Human Coronaviruses: A Review of Virus–Host Interactions|journal=Diseases|volume=4|issue=3|pages=26|doi=10.3390/diseases4030026|issn=2079-9721|pmc=5456285|pmid=28933406|quote=See Table 1.|doi-access=free}}</ref> It is an [[Viral envelope|enveloped]], [[Sense (molecular biology)|positive-sense]], [[RNA|single-stranded]] [[RNA virus]] which enters its host cell by binding to the [[Alanine aminopeptidase|APN receptor]].<ref>{{cite book|vauthors=Fehr AR, Perlman S|chapter=Coronaviruses: An Overview of Their Replication and Pathogenesis |title=Coronaviruses|date=2015|series=Methods in Molecular Biology|publisher=Springer|volume=1282|pages=1–23|doi=10.1007/978-1-4939-2438-7_1|isbn=978-1-4939-2438-7|pmc=4369385|pmid=25720466|quote=See Table 1.|veditors=Maier HJ, Bickerton E, Britton P}}</ref> Along with [[Human coronavirus OC43]] (a member of the ''[[Betacoronavirus]]'' genus), it is one of the viruses responsible for the [[common cold]].<ref>{{cite journal | pmid = 21849456 | year = 2011 | last1 = Lau | first1 = S. K. | last2 = Lee | first2 = P. | last3 = Tsang | first3 = A. K. | last4 = Yip | first4 = C. C. | last5 = Tse | first5 = H. | last6 = Lee | first6 = R. A. | last7 = So | first7 = L. Y. | last8 = Lau | first8 = Y. L. | last9 = Chan | first9 = K. H. | last10 = Woo | first10 = P. C. | last11 = Yuen | first11 = K. Y. | title = Molecular epidemiology of human coronavirus OC43 reveals evolution of different genotypes over time and recent emergence of a novel genotype due to natural recombination | journal = Journal of Virology | volume = 85 | issue = 21 | pages = 11325–11337 | doi = 10.1128/JVI.05512-11 | pmc = 3194943 }}</ref><ref>{{cite journal | pmid = 20554810 | year = 2010 | last1 = Gaunt | first1 = E. R. | last2 = Hardie | first2 = A. | last3 = Claas | first3 = E. C. | last4 = Simmonds | first4 = P. | last5 = Templeton | first5 = K. E. | title = Epidemiology and clinical presentations of the four human coronaviruses 229E, HKU1, NL63, and OC43 detected over 3 years using a novel multiplex real-time PCR method | journal = Journal of Clinical Microbiology | volume = 48 | issue = 8 | pages = 2940–2947 | doi = 10.1128/JCM.00636-10 | pmc = 2916580 }}</ref> HCoV-229E is a member of the genus ''[[Alphacoronavirus]]'' and subgenus ''Duvinacovirus''.<ref name="ICTV10">{{cite web|url=https://ictv.global/taxonomy|title=Virus Taxonomy: 2018 Release|date=October 2018|website=International Committee on Taxonomy of Viruses (ICTV)|language=en|access-date=13 January 2019}}</ref><ref name=":02">{{Cite journal|last1=Woo|first1=Patrick C. Y.|last2=Huang|first2=Yi|last3=Lau|first3=Susanna K. P.|last4=Yuen|first4=Kwok-Yung|date=2010-08-24|title=Coronavirus Genomics and Bioinformatics Analysis|journal=Viruses|volume=2|issue=8|pages=1804–1820|doi=10.3390/v2081803|issn=1999-4915|pmc=3185738|pmid=21994708|quote=Figure 2. Phylogenetic analysis of RNA-dependent RNA polymerases (Pol) of coronaviruses with complete genome sequences available. The tree was constructed by the neighbor-joining method and rooted using Breda virus polyprotein.|doi-access=free}}</ref>


==Transmission==
==Transmission==
Line 16: Line 16:


==Signs and symptoms==
==Signs and symptoms==
HCoV-229E is associated with a range of [[respiratory symptom]]s, ranging from the [[common cold]] to high-morbidity outcomes such as [[pneumonia]] and [[bronchiolitis]]. However, such high [[Disease#Morbidity|morbidity]] outcomes are almost always seen in cases with [[co-infection]] with other [[respiratory pathogen]]s; there is a single published case report to date of a 229E infection that caused [[acute respiratory distress syndrome]] (ARDS) in an otherwise healthy patient having no detectable co-infection with another [[pathogen]].<ref>A Rare Case of Human Coronavirus 229E Associated with Acute Respiratory Distress Syndrome in a Healthy Adult. Vassilara F, Spyridaki A, Pothitos G, Deliveliotou A, Papadopoulos A. Case Rep Infect Dis. 2018 Apr 15;2018:6796839. doi: 10.1155/2018/6796839. eCollection 2018. PMID 29850307 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925015/ Free PMC Article]</ref> HCoV-229E is also among the coronaviruses most frequently codetected with other respiratory viruses, particularly with [[human respiratory syncytial virus]] (HRSV).<ref>Pene, F., A. Merlat, A. Vabret, F. Rozenberg, A. Buzyn, F. Dreyfus, A. Cariou, F. Freymuth, and P. Lebon. 2003. Coronavirus 229E related pneumonia in immunocompromised patients. Clin. Infect. Dis. 37:929–932. [PubMed]</ref><ref>Vabret, A., T. Mourez, S. Gouarin, J. Petitjean, and F. Freymuth. 2003. An outbreak of coronavirus OC43 respiratory infection in Normandy, France. Clin. Infect. Dis. 36:985–989. [PubMed]</ref><ref>Woo, P. C. Y., S. K. P. Lau, H. Tsoi, Y. Huang, R. W. S. Poon, C. M. Chu, R. A. Lee, W. K. Luk, G. K. M. Wong, B. H. L. Wong, V. C. C. Cheng, B. S. F. Tang, A. K. L. Wu, R. W. H. Yung, H. Chen, Y. Guan, K. H. Chan, and K. Y. Yuen. 2005. Clinical and molecular epidemiological features of coronavirus HKU1 associated community acquired pneumonia. J. Infect. Dis. 192:1898–1907. [PubMed]</ref>
HCoV-229E is associated with a range of [[respiratory symptom]]s, ranging from the [[common cold]] to high-morbidity outcomes such as [[pneumonia]] and [[bronchiolitis]]. However, such high [[Disease#Morbidity|morbidity]] outcomes are almost always seen in cases with [[co-infection]] with other [[respiratory pathogen]]s; there is a single published case report to date of a 229E infection that caused [[acute respiratory distress syndrome]] (ARDS) in an otherwise healthy patient having no detectable co-infection with another [[pathogen]].<ref>{{cite journal | pmid = 29850307 | year = 2018 | last1 = Vassilara | first1 = F. | last2 = Spyridaki | first2 = A. | last3 = Pothitos | first3 = G. | last4 = Deliveliotou | first4 = A. | last5 = Papadopoulos | first5 = A. | title = A Rare Case of Human Coronavirus 229E Associated with Acute Respiratory Distress Syndrome in a Healthy Adult | journal = Case Reports in Infectious Diseases | volume = 2018 | pages = 1–4 | doi = 10.1155/2018/6796839 | pmc = 5925015 | doi-access = free }}</ref> HCoV-229E is also among the coronaviruses most frequently codetected with other respiratory viruses, particularly with [[human respiratory syncytial virus]] (HRSV).<ref>{{cite journal | pmid = 13130404 | year = 2003 | last1 = Pene | first1 = F. | last2 = Merlat | first2 = A. | last3 = Vabret | first3 = A. | last4 = Rozenberg | first4 = F. | last5 = Buzyn | first5 = A. | last6 = Dreyfus | first6 = F. | last7 = Cariou | first7 = A. | last8 = Freymuth | first8 = F. | last9 = Lebon | first9 = P. | title = Coronavirus 229E-related pneumonia in immunocompromised patients | journal = Clinical Infectious Diseases | volume = 37 | issue = 7 | pages = 929–932 | doi = 10.1086/377612 | pmc = 7107892 }}</ref><ref>{{cite journal | pmid = 12684910 | year = 2003 | last1 = Vabret | first1 = A. | last2 = Mourez | first2 = T. | last3 = Gouarin | first3 = S. | last4 = Petitjean | first4 = J. | last5 = Freymuth | first5 = F. | title = An outbreak of coronavirus OC43 respiratory infection in Normandy, France | journal = Clinical Infectious Diseases | volume = 36 | issue = 8 | pages = 985–989 | doi = 10.1086/374222 | pmc = 7109673 }}</ref><ref>{{cite journal | pmid = 16267760 | year = 2005 | last1 = Woo | first1 = P. C. | last2 = Lau | first2 = S. K. | last3 = Tsoi | first3 = H. W. | last4 = Huang | first4 = Y. | last5 = Poon | first5 = R. W. | last6 = Chu | first6 = C. M. | last7 = Lee | first7 = R. A. | last8 = Luk | first8 = W. K. | last9 = Wong | first9 = G. K. | last10 = Wong | first10 = B. H. | last11 = Cheng | first11 = V. C. | last12 = Tang | first12 = B. S. | last13 = Wu | first13 = A. K. | last14 = Yung | first14 = R. W. | last15 = Chen | first15 = H. | last16 = Guan | first16 = Y. | last17 = Chan | first17 = K. H. | last18 = Yuen | first18 = K. Y. | title = Clinical and molecular epidemiological features of coronavirus HKU1-associated community-acquired pneumonia | journal = The Journal of Infectious Diseases | volume = 192 | issue = 11 | pages = 1898–2707 | doi = 10.1086/497151 | pmc = 7110183 }}</ref>


==Epidemiology==
==Epidemiology==
HCoV-229E is one of the seven human coronaviruses which include [[Human coronavirus NL63|HCoV-NL63]], [[Human coronavirus OC43|HCoV-OC43]], [[Human coronavirus HKU1|HCoV-HKU1]],
HCoV-229E is one of the seven human coronaviruses which include [[Human coronavirus NL63|HCoV-NL63]], [[Human coronavirus OC43|HCoV-OC43]], [[Human coronavirus HKU1|HCoV-HKU1]],
[[Middle East respiratory syndrome-related coronavirus|MERS-CoV]], [[Severe acute respiratory syndrome coronavirus|SARS-CoV-1]], and [[Severe acute respiratory syndrome coronavirus 2|SARS-CoV-2]] and are globally distributed.<ref>Fields, B. N., D. M. Knipe, and P. M. Howley (ed.). 1996. Fields virology, 3rd ed. Lippincott-Raven, Philadelphia, PA.</ref><ref>Hoek, L. van der, P. Krzysztof, and B. Berkhout. 2006. Human coronavirus NL63, a new respiratory virus. FEMS Microbiol. Rev. 30:760–773. [PubMed]</ref> However, the viruses were detected in different parts of the world at different times of the year.<ref>Esper, F., C. Weibel, D. Ferguson, M. L. Landry, and J. S. Kahn. 2006. Coronavirus HKU1 infection in the United States. Emerg. Infect. Dis. 12:775–779. [PMC free article] [PubMed]</ref><ref>Gerna, G., E. Percivalle, A. Sarasini, G. Campanini, A. Piralla, F. Rovida, E. Genini, A. Marchi, and F. Baldanti. 2007. Human respiratory coronavirus HKU1 versus other coronavirus infections in Italian hospitalised patients. J. Clin. Virol. 38:244–250. [PubMed]</ref><ref>Kaye, H. S., H. B. Marsh, and W. R. Dowdle. 1971. Seroepidemiologic survey of coronavirus (strain OC 43) related infections in a children's population. Am. J. Epidemiol. 94:43–49. [PubMed]</ref> A [[National Center for Biotechnology Information|NCBI]]-study found a previous HCoV-229E infection in 42.9% – 50.0% of children of 6–12 months of age and in 65% of those 2.5–3.5 years of age.<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957994/#R33 Effects of Coronavirus Infections in Children]</ref>
[[Middle East respiratory syndrome-related coronavirus|MERS-CoV]], [[Severe acute respiratory syndrome coronavirus|SARS-CoV-1]], and [[Severe acute respiratory syndrome coronavirus 2|SARS-CoV-2]] and are globally distributed.<ref>Fields, B. N., D. M. Knipe, and P. M. Howley (ed.). 1996. Fields virology, 3rd ed. Lippincott-Raven, Philadelphia, PA.</ref><ref>{{cite journal | pmid = 16911043 | year = 2006 | last1 = Van Der Hoek | first1 = L. | last2 = Pyrc | first2 = K. | last3 = Berkhout | first3 = B. | title = Human coronavirus NL63, a new respiratory virus | journal = FEMS Microbiology Reviews | volume = 30 | issue = 5 | pages = 760–773 | doi = 10.1111/j.1574-6976.2006.00032.x | pmc = 7109777 }}</ref> However, the viruses were detected in different parts of the world at different times of the year.<ref>{{cite journal | pmid = 16704837 | year = 2006 | last1 = Esper | first1 = F. | last2 = Weibel | first2 = C. | last3 = Ferguson | first3 = D. | last4 = Landry | first4 = M. L. | last5 = Kahn | first5 = J. S. | title = Coronavirus HKU1 infection in the United States | journal = Emerging Infectious Diseases | volume = 12 | issue = 5 | pages = 775–779 | doi = 10.3201/eid1205.051316 | pmc = 3374449 }}</ref><ref>{{cite journal | pmid = 17222582 | year = 2007 | last1 = Gerna | first1 = G. | last2 = Percivalle | first2 = E. | last3 = Sarasini | first3 = A. | last4 = Campanini | first4 = G. | last5 = Piralla | first5 = A. | last6 = Rovida | first6 = F. | last7 = Genini | first7 = E. | last8 = Marchi | first8 = A. | last9 = Baldanti | first9 = F. | title = Human respiratory coronavirus HKU1 versus other coronavirus infections in Italian hospitalised patients | journal = Journal of Clinical Virology | volume = 38 | issue = 3 | pages = 244–250 | doi = 10.1016/j.jcv.2006.12.008 | pmc = 7108341 }}</ref><ref>{{cite journal | pmid = 5556222 | year = 1971 | last1 = Kaye | first1 = H. S. | last2 = Marsh | first2 = H. B. | last3 = Dowdle | first3 = W. R. | title = Seroepidemiologic survey of coronavirus (Strain OC 43) related infections in a children's population | journal = American Journal of Epidemiology | volume = 94 | issue = 1 | pages = 43–49 | doi = 10.1093/oxfordjournals.aje.a121293 | pmc = 7109649 }}</ref> A [[National Center for Biotechnology Information|NCBI]]-study found a previous HCoV-229E infection in 42.9% – 50.0% of children of 6–12 months of age and in 65% of those 2.5–3.5 years of age.<ref>{{cite journal | pmid = 20113545 | year = 2010 | last1 = Principi | first1 = N. | last2 = Bosis | first2 = S. | last3 = Esposito | first3 = S. | title = Effects of coronavirus infections in children | journal = Emerging Infectious Diseases | volume = 16 | issue = 2 | pages = 183–188 | doi = 10.3201/eid1602.090469 | pmc = 2957994 }}</ref>


==Virology==
==Virology==

Latest revision as of 02:17, 12 October 2023

Human coronavirus 229E
Transmission electron micrograph of human coronavirus 229E
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Pisuviricota
Class: Pisoniviricetes
Order: Nidovirales
Family: Coronaviridae
Genus: Alphacoronavirus
Subgenus: Duvinacovirus
Species:
Human coronavirus 229E

Human coronavirus 229E (HCoV-229E) is a species of coronavirus which infects humans and bats.[1] It is an enveloped, positive-sense, single-stranded RNA virus which enters its host cell by binding to the APN receptor.[2] Along with Human coronavirus OC43 (a member of the Betacoronavirus genus), it is one of the viruses responsible for the common cold.[3][4] HCoV-229E is a member of the genus Alphacoronavirus and subgenus Duvinacovirus.[5][6]

Transmission[edit]

HCoV-229E transmits via droplet-respiration and fomites.

Signs and symptoms[edit]

HCoV-229E is associated with a range of respiratory symptoms, ranging from the common cold to high-morbidity outcomes such as pneumonia and bronchiolitis. However, such high morbidity outcomes are almost always seen in cases with co-infection with other respiratory pathogens; there is a single published case report to date of a 229E infection that caused acute respiratory distress syndrome (ARDS) in an otherwise healthy patient having no detectable co-infection with another pathogen.[7] HCoV-229E is also among the coronaviruses most frequently codetected with other respiratory viruses, particularly with human respiratory syncytial virus (HRSV).[8][9][10]

Epidemiology[edit]

HCoV-229E is one of the seven human coronaviruses which include HCoV-NL63, HCoV-OC43, HCoV-HKU1, MERS-CoV, SARS-CoV-1, and SARS-CoV-2 and are globally distributed.[11][12] However, the viruses were detected in different parts of the world at different times of the year.[13][14][15] A NCBI-study found a previous HCoV-229E infection in 42.9% – 50.0% of children of 6–12 months of age and in 65% of those 2.5–3.5 years of age.[16]

Virology[edit]

HCoV-229E is one of seven known coronaviruses to infect humans. The other six are:[17]

Research[edit]

Chloroquine, a zinc ionophore, inhibits the replication of Human coronavirus 229E in cell culture.[18]

Human HCoV-229E, and human HCoV-NL63, likely originated from bats.[19]

History[edit]

A researcher at the University of Chicago, Dorothy Hamre, first identified 229E in 1965.[20][21]

See also[edit]

References[edit]

  1. ^ Lim, Yvonne Xinyi; Ng, Yan Ling; Tam, James P.; Liu, Ding Xiang (2016-07-25). "Human Coronaviruses: A Review of Virus–Host Interactions". Diseases. 4 (3): 26. doi:10.3390/diseases4030026. ISSN 2079-9721. PMC 5456285. PMID 28933406. See Table 1.
  2. ^ Fehr AR, Perlman S (2015). "Coronaviruses: An Overview of Their Replication and Pathogenesis". In Maier HJ, Bickerton E, Britton P (eds.). Coronaviruses. Methods in Molecular Biology. Vol. 1282. Springer. pp. 1–23. doi:10.1007/978-1-4939-2438-7_1. ISBN 978-1-4939-2438-7. PMC 4369385. PMID 25720466. See Table 1.
  3. ^ Lau, S. K.; Lee, P.; Tsang, A. K.; Yip, C. C.; Tse, H.; Lee, R. A.; So, L. Y.; Lau, Y. L.; Chan, K. H.; Woo, P. C.; Yuen, K. Y. (2011). "Molecular epidemiology of human coronavirus OC43 reveals evolution of different genotypes over time and recent emergence of a novel genotype due to natural recombination". Journal of Virology. 85 (21): 11325–11337. doi:10.1128/JVI.05512-11. PMC 3194943. PMID 21849456.
  4. ^ Gaunt, E. R.; Hardie, A.; Claas, E. C.; Simmonds, P.; Templeton, K. E. (2010). "Epidemiology and clinical presentations of the four human coronaviruses 229E, HKU1, NL63, and OC43 detected over 3 years using a novel multiplex real-time PCR method". Journal of Clinical Microbiology. 48 (8): 2940–2947. doi:10.1128/JCM.00636-10. PMC 2916580. PMID 20554810.
  5. ^ "Virus Taxonomy: 2018 Release". International Committee on Taxonomy of Viruses (ICTV). October 2018. Retrieved 13 January 2019.
  6. ^ Woo, Patrick C. Y.; Huang, Yi; Lau, Susanna K. P.; Yuen, Kwok-Yung (2010-08-24). "Coronavirus Genomics and Bioinformatics Analysis". Viruses. 2 (8): 1804–1820. doi:10.3390/v2081803. ISSN 1999-4915. PMC 3185738. PMID 21994708. Figure 2. Phylogenetic analysis of RNA-dependent RNA polymerases (Pol) of coronaviruses with complete genome sequences available. The tree was constructed by the neighbor-joining method and rooted using Breda virus polyprotein.
  7. ^ Vassilara, F.; Spyridaki, A.; Pothitos, G.; Deliveliotou, A.; Papadopoulos, A. (2018). "A Rare Case of Human Coronavirus 229E Associated with Acute Respiratory Distress Syndrome in a Healthy Adult". Case Reports in Infectious Diseases. 2018: 1–4. doi:10.1155/2018/6796839. PMC 5925015. PMID 29850307.
  8. ^ Pene, F.; Merlat, A.; Vabret, A.; Rozenberg, F.; Buzyn, A.; Dreyfus, F.; Cariou, A.; Freymuth, F.; Lebon, P. (2003). "Coronavirus 229E-related pneumonia in immunocompromised patients". Clinical Infectious Diseases. 37 (7): 929–932. doi:10.1086/377612. PMC 7107892. PMID 13130404.
  9. ^ Vabret, A.; Mourez, T.; Gouarin, S.; Petitjean, J.; Freymuth, F. (2003). "An outbreak of coronavirus OC43 respiratory infection in Normandy, France". Clinical Infectious Diseases. 36 (8): 985–989. doi:10.1086/374222. PMC 7109673. PMID 12684910.
  10. ^ Woo, P. C.; Lau, S. K.; Tsoi, H. W.; Huang, Y.; Poon, R. W.; Chu, C. M.; Lee, R. A.; Luk, W. K.; Wong, G. K.; Wong, B. H.; Cheng, V. C.; Tang, B. S.; Wu, A. K.; Yung, R. W.; Chen, H.; Guan, Y.; Chan, K. H.; Yuen, K. Y. (2005). "Clinical and molecular epidemiological features of coronavirus HKU1-associated community-acquired pneumonia". The Journal of Infectious Diseases. 192 (11): 1898–2707. doi:10.1086/497151. PMC 7110183. PMID 16267760.
  11. ^ Fields, B. N., D. M. Knipe, and P. M. Howley (ed.). 1996. Fields virology, 3rd ed. Lippincott-Raven, Philadelphia, PA.
  12. ^ Van Der Hoek, L.; Pyrc, K.; Berkhout, B. (2006). "Human coronavirus NL63, a new respiratory virus". FEMS Microbiology Reviews. 30 (5): 760–773. doi:10.1111/j.1574-6976.2006.00032.x. PMC 7109777. PMID 16911043.
  13. ^ Esper, F.; Weibel, C.; Ferguson, D.; Landry, M. L.; Kahn, J. S. (2006). "Coronavirus HKU1 infection in the United States". Emerging Infectious Diseases. 12 (5): 775–779. doi:10.3201/eid1205.051316. PMC 3374449. PMID 16704837.
  14. ^ Gerna, G.; Percivalle, E.; Sarasini, A.; Campanini, G.; Piralla, A.; Rovida, F.; Genini, E.; Marchi, A.; Baldanti, F. (2007). "Human respiratory coronavirus HKU1 versus other coronavirus infections in Italian hospitalised patients". Journal of Clinical Virology. 38 (3): 244–250. doi:10.1016/j.jcv.2006.12.008. PMC 7108341. PMID 17222582.
  15. ^ Kaye, H. S.; Marsh, H. B.; Dowdle, W. R. (1971). "Seroepidemiologic survey of coronavirus (Strain OC 43) related infections in a children's population". American Journal of Epidemiology. 94 (1): 43–49. doi:10.1093/oxfordjournals.aje.a121293. PMC 7109649. PMID 5556222.
  16. ^ Principi, N.; Bosis, S.; Esposito, S. (2010). "Effects of coronavirus infections in children". Emerging Infectious Diseases. 16 (2): 183–188. doi:10.3201/eid1602.090469. PMC 2957994. PMID 20113545.
  17. ^ Leung, Daniel (20 January 2019). "Coronaviruses (including SARS)". Infectious Disease Advisor. Decision Support in Medicine, LLC. Retrieved 1 August 2020.
  18. ^ de Wilde, Adriaan H.; Jochmans, Dirk; Posthuma, Clara C.; Zevenhoven-Dobbe, Jessika C.; van Nieuwkoop, Stefan; Bestebroer, Theo M.; van den Hoogen, Bernadette G.; Neyts, Johan; Snijder, Eric J. (August 2014). "Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture". Antimicrobial Agents and Chemotherapy. 58 (8): 4875–4884. doi:10.1128/AAC.03011-14. PMC 4136071. PMID 24841269.
  19. ^ Tao, Y.; Shi, M.; Chommanard, C.; Queen, K.; Zhang, J.; Markotter, W.; Kuzmin, I. V.; Holmes, E. C.; Tong, S. (2017). "Surveillance of Bat Coronaviruses in Kenya Identifies Relatives of Human Coronaviruses NL63 and 229E and Their Recombination History". Journal of Virology. 91 (5). doi:10.1128/JVI.01953-16. PMC 5309958. PMID 28077633.
  20. ^ Knapp, Alex. "The Secret History Of The First Coronavirus". Forbes. Retrieved 2020-05-06.
  21. ^ Hamre, D.; Procknow, J. J. (1966-01-01). "A New Virus Isolated from the Human Respiratory Tract". Experimental Biology and Medicine. 121 (1): 190–193. doi:10.3181/00379727-121-30734. ISSN 1535-3702. PMID 4285768. S2CID 1314901.

External links[edit]

Wikispecies has information related to Human coronavirus 229E.
Retrieved from "https://en.wikipedia.org/w/index.php?title=Human_coronavirus_229E&oldid=1179733921"