1-ethylpiperidine

Structural formula
General
Surname	1-ethylpiperidine
other names	N -ethylpiperidine
Molecular formula	C 7 H 15 N
Brief description	colorless liquid with an unpleasant odor
External identifiers / databases
EC number	212-161-6
ECHA InfoCard	100,011,055
PubChem	13007
ChemSpider	12466
Wikidata	Q22829159
properties
Molar mass	113.20 g mol −1
Physical state	liquid
density	0.82 g cm −3 (20 ° C)
Melting point	<−50 ° C
boiling point	131 ° C
Vapor pressure	10.3 h Pa (20 ° C); 45 hPa (50 ° C); 85 hPa (65 ° C);
solubility	heavy in water (6 g l −1 at 20 ° C); miscible with ethanol and most organic solvents;
Refractive index	1.444 (20 ° C)
safety instructions
H and P phrases	H: 225-301-312-314-331
	P: 210-261-305 + 351 + 338
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C

1-Ethylpiperidine ( IUPAC ) is an organic chemical compound from the group of cyclic , tertiary amines . The compound is used as a starting material for organic syntheses and as an intermediate in pharmaceutical syntheses .

Extraction and presentation

1-Ethylpiperidine can be prepared by reacting piperidine with ethanol at 200 ° C. and pressures around 75 bar over Raney nickel catalysts .

properties

Physical Properties

N-Ethylpiperidine has a relative gas density of 3.91 (density ratio to dry air at the same temperature and pressure ) and a relative density of the steam-air mixture of 1.03 (density ratio to dry air at 20 ° C and normal pressure ). In addition, 1-ethylpiperidine has a vapor pressure of 10.3 hPa at 20 ° C, 45 hPa at 50 ° C and 85 hPa at 65 ° C. The dynamic viscosity is 0.88 mPa · s at 20 ° C.

Chemical properties

N-Ethylpiperidine is a highly flammable liquid from the group of aliphatic , tertiary and cyclic amines or nitrogen heterocycles. The compound is sparingly soluble in water, but miscible with ethanol and most organic solvents . In addition, 1-ethylpiperidine is of medium or low volatility.

use

1-Ethylpiperidine is used in organic syntheses and as an intermediate in pharmaceutical syntheses . It is also used to determine the content of penicillin salts .

safety instructions

The vapors of 1-ethylpiperidine can form explosive mixtures with air. 1-Ethylpiperidine has a lower explosion limit (LEL) of approx. 1.9% by volume and an upper explosion limit (UEL) of approx. 12.1% by volume. The ignition temperature is 205 ° C. The substance therefore falls into temperature class T3. With a flash point of 17 ° C, 1-ethylpiperidine is highly flammable.

Web links

Commons : 1-Ethylpiperidine - Collection of pictures, videos, and audio files

Individual evidence

↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l Entry on N-Ethylpiperidine in the GESTIS substance database of the IFA , accessed on July 25, 2019(JavaScript required) .
↑ ^a ^b entry on 1-ethylpiperidine. In: Römpp Online . Georg Thieme Verlag, accessed on July 25, 2019.
↑ ^a ^b Data sheet 1-Ethylpiperidine from Sigma-Aldrich , accessed on July 27, 2019 ( PDF ).
^ Charles F. Winans, Homer Adkins: THE ALKYLATION OF AMINES AS CATALYZED BY NICKEL. In: Journal of the American Chemical Society. 54, 1932, p. 306, doi : 10.1021 / ja01340a046 .

[GESTIS-1] ↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l Entry on N-Ethylpiperidine in the GESTIS substance database of the IFA , accessed on July 25, 2019(JavaScript required) .

[RÖMPP-2] try on 1-ethylpiperidine. In: Römpp Online . Georg Thieme Verlag, accessed on July 25, 2019.

[Aldrich-3] Data sheet 1-Ethylpiperidine from Sigma-Aldrich , accessed on July 27, 2019 ( PDF ).

[4] Charles F. Winans, Homer Adkins: THE ALKYLATION OF AMINES AS CATALYZED BY NICKEL. In: Journal of the American Chemical Society. 54, 1932, p. 306, doi : 10.1021 / ja01340a046 .