1B-LSD

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Structural formula
Structural formula of 1B-LSD
General
Surname 1B-LSD
other names
  • (6a R , 9 R ) -4-Butyryl- N , N -diethyl-7-methyl-4,6,6a, 7,8,9-hexahydroindolo [4,3- fg ] quinoline-9-carboxamide
  • 1-butyryl- D -lyserg acid diethylamide
Molecular formula C 24 H 32 N 3 O 2
External identifiers / databases
CAS number not forgiven
Wikidata Q60983498
Drug information
Mechanism of action

partial agonist at serotonin (5-HT 2A ) receptors

properties
Molar mass 394.24 g mol −1
safety instructions
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

1B-LSD (1-butyryl D -lysergsäurediethylamid) is a psychedelic acting psychotropic substance and research chemical . 1B-LSD is a derivative of lysergic acid , which occurs naturally in ergot alkaloids , as well as an analogue of LSD and a homologue of 1P-LSD and ALD-52 .

chemistry

Chemically, 1B-LSD belongs to the Ergoline structural class . The tetracyclic ergoline is characteristic of the chemical structure of ergot alkaloids . In contrast to LSD, 1B-LSD has an additional N 1 - butyryl group . Chemical modifications in the N 1 position are among the most frequently carried out changes to the ergoline system, since the indole nitrogen is easily accessible for alkylations , acylations , Mannich reactions and Michael additions .

  • Basic body of the Ergoline

  • Structural formula of LSD

  • Structural formula of ALD-52 (1-acetyl- D- LSD)

  • Structural formula of 1P-LSD (1-Propionyl- D -LSD)

  • Structural formula of 1B-LSD (1-butyryl- D -LSD)

pharmacology

It is assumed that 1B-LSD (like the acyl homologues 1P-LSD and ALD-52 ) is deacylated in the body with cleavage of butyric acid to form LSD , which studies with human blood serum have shown.

See also

Web links

  • isomerdesign.com: 1B-LSD (English)

Individual evidence

  1. ↑ a b c Lea Wagmann, Lilian HJ Richter a. a .: In vitro metabolic fate of nine LSD-based new psychoactive substances and their analytical detectability in different urinary screening procedures. In: Analytical and Bioanalytical Chemistry . 2019, doi : 10.1007 / s00216-018-1558-9 .
  2. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  3. ↑ Petr Bulej, Ladislav Cvak: Chemical modifications of ergot alkaloids . In: Vladimir Kren, Ladislav Cvak (eds.): Ergot: The Genus Claviceps. Medicinal and Aromatic Plants - Industrial Profiles . CRC Press, 2004, ISBN 0203304195 , pp. 202-230.
  4. ↑ AL Halberstadt, M. Chatha u. a .: Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of d-lysergic acid diethylamide (LSD). In: Neuropharmacology. November 2019, doi : 10.1016 / j.neuropharm.2019.107856 , PMID 31756337 .
  5. ↑ Simon D. Brandt, Pierce V. Kavanagh et al. a .: Return of the lysergamides. Part V: Analytical and behavioral characterization of 1 ‐ butanoyl-d-lysergic acid diethylamide (1B ‐ LSD). In: Drug Testing and Analysis. 2019, doi : 10.1002 / dta.2613 .