Albert Hewett Coons

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Albert Hewett Coons (born June 28, 1912 in Gloversville , New York , † September 30, 1978 in Brookline , Massachusetts ) was an American physician ( pathology , immunology ). He was the first to develop and apply immunofluorescence techniques in the 1940s .

Coons studied at Williams College in Williamstown (Massachusetts) with a bachelor's degree in 1933, and at Harvard Medical School , from which he graduated with an MD . This was followed by residency at Massachusetts General Hospital , which received a fellowship in bacteriology and immunology in the Thorndike Memorial Laboratory there with Hans Zinsser . In 1939, during a stay in Berlin at the Charité , he came up with the idea of detecting antigens using specific antibodies labeled with fluorescent molecules . On his return to Boston, he researched it, he said, the chemical techniques with the organic chemist Louis Fieser developed and antibodies against pneumococcal tested, he said fluorescent molecules anthracene - isocyanate anhängte. The antibodies retained their effect and led to the flocculation of the pneumococci, which was now visible under UV light under the microscope.

Coons then further developed the techniques of immunofluorescence (immunohistochemistry). After his military service as a pathologist and laboratory manager in the US Army Medical Corps in the Pacific War, he returned to Harvard as a scientist from 1946 and became an instructor there in 1947. In 1953 he became a Career Investigator for the American Heart Association and a visiting professor at Harvard. In 1970 he received a chair in the department of bacteriology and immunology at Harvard Medical School, from 1971 in the department of pathology.

He was President of the Histochemistry Society and in the years 1960/1961 of the American Association of Immunologists as well as several honorary doctorates. In 1959 he received the Albert Lasker Award for Basic Medical Research , in 1961 the Paul Ehrlich and Ludwig Darmstaedter Prize , in 1962 a Gairdner Foundation International Award and the Passano Award and in 1966 the Emil von Behring Prize . In 1954 he was elected to the American Academy of Arts and Sciences , in 1962 to the National Academy of Sciences .

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Individual evidence

  1. 1925 to 1940 Professor of Bacteriology and Immunology at Harvard
  2. He was friends with the senior physician Kurt Apitz in the pathology department. McDevitt in Biographical Memoirs Nat. Acad. Sc.