Aminophylline

Structural formula
General
Non-proprietary name	Aminophylline
other names	1,3-dimethyl-7 H -purine-2,6-dione
Molecular formula	C 16 H 24 N 10 O 4
External identifiers / databases
EC number	206-264-5
ECHA InfoCard	100.005.696
PubChem	9433
DrugBank	DB01223
Wikidata	Q471763
Drug information
ATC code	R03 DA05
Drug class	Bronchospasmolytic; Cardiotonic;
properties
Molar mass	420.44 g mol −1
Physical state	firmly
Melting point	269-270 ° C
solubility	soluble in water (50 mg / ml at 20 ° C); insoluble in ethanol;
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances danger
H and P phrases	H: 301
	P: 301 + 310
Toxicological data	243 mg kg −1 ( LD 50 , rat , oral )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Aminophylline is a drug from the group of methyl xanthines . It is the ethylenediamine salt of theophylline and, like this, can be used as a bronchospasmolytic in bronchial asthma . It also stimulates the central nervous system , diuresis and gastric acid secretion .

The plasma half-life is approximately 7 to 9 hours. Around 60% of the active substance is bound to proteins in the blood .

Trade names

Monopreparations Euphyllin (A), Aminophyllin Amino (CH), Aminophyllin (D), Aminomal (I)

↑ ^a ^b ^c ^d ^e ^f Datasheet Aminophylline, ≥98%, powder from Sigma-Aldrich , accessed on July 4, 2013 ( PDF ).
↑ ^a ^b Entry on aminophylline in the DrugBank of the University of Alberta .