Andreas Trumpp

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Andreas Trumpp, 2020

Andreas Trumpp (born March 6, 1964 in Heilbronn ) is a German biologist and cancer researcher. Since 2008 he has been head of the stem cells and cancer department at the German Cancer Research Center (DKFZ) . He also heads the Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM gGmbH), a joint institution of the Dietmar Hopp Foundation and the DKFZ.

Andreas Trumpp's research focuses on the use of stem cell research to develop new treatment strategies against cancer . He is particularly concerned with hematopoietic stem cells and mechanisms and changes in the hematopoietic system , which is responsible for hematological diseases, such as. B. leukemia , are responsible. In addition, he deals with questions of therapy resistance of cancer cells and with mechanisms that lead to the metastatic spread of solid tumors.

Life

After studying biology at the universities of Erlangen and Freiburg , Andreas Trumpp received his doctorate in 1992 at the European Molecular Biology Laboratory (EMBL) in Heidelberg. From 1993 to 2000 he was a postdoc at the University of California in San Francisco in the laboratory of Nobel Prize winner J. Michael Bishop . In 2000 he was appointed research group leader at the Swiss Institute for Experimental Cancer Research (ISREC) in Epalinges / Lausanne, and in 2005 he was also appointed assistant professor at the École Polytechnique Fédérale de Lausanne .

After being appointed head of the “Stem Cells and Cancer” department at the German Cancer Research Center , he became the founding director of the Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM gGmbH) in 2008. HI-STEM was founded in 2008 as a public-private partnership between the DKFZ and the Dietmar Hopp Foundation. Its aim is to develop new approaches for the diagnosis and treatment of cancer through top-class basic research on normal and malignant stem cells.

In 2013 he was one of the three founders of the German stem cell network (GSCN) in which he is also a member of the executive board. In addition, since 2016 he has been the spokesman for the research focus cell and tumor biologist at the DKFZ and co-director of the DKFZ-ZMBH alliance and a member of the board of directors of the National Center for Tumor Diseases (NCT) . Since 2018 he has also been a board member of the "European Association of Cancer Research - EACR".

Andreas Trumpp is married and has three children.

research

One of Trumpp's most important research achievements is the discovery of so-called “sleeping” stem cells. This condition protects the stem cells from damage that can lead to cancer, but also makes malignant cancer stem cells resistant to cancer therapies. His work on breast cancer led to the discovery of malignant cancer stem cells that circulate in the blood and are responsible for metastatic spread in the body. In the case of pancreatic cancer, on the other hand, which has so far hardly been treated successfully, researchers working with Andreas Trumpp and Martin Sprick found out how tumor cells develop resistance to certain cancer drugs.

As part of his work on starting points for new therapies in acute myeloid leukemia (AML) , Trumpp was able to discover a new connection between changes in the amino acid metabolism of cancer cells and epigenetic changes. For the cancer gene MYC, Trumpp and colleagues discovered a complex "super-enhancer" whose activity is jointly responsible for the therapy response and the development of resistance. Together with Claudia Lengerke and Helmut Salih , the Trumpp laboratory was recently able to show how cancer stem cells in AML can hide from the immune system and how this camouflage can be therapeutically lifted.

Awards

Publications

Trumpp has so far published over 200 scientific articles in specialist journals, including numerous publications in top-class international journals such as Nature , Science , Cell, Nature Medicine and Cell Stem Cell. In 2019 he was recognized by the Web of Science Group as a Highly Cited Researcher , a distinction for the leading one percent of the world's most cited researchers in their respective fields.

Web links

Individual evidence

  1. ↑ Heidelberg - High distinction for stem cell researcher Andreas Trumpp - /// METROPOLIC REGION RHEIN-NECKAR NEWS & EVENTS. Retrieved January 23, 2020 (German).
  2. ↑ Five years of successful cancer stem cell research at HI-STEM. Retrieved January 23, 2020 .
  3. ↑ German stem cell network founded | MDC Berlin. Retrieved January 23, 2020 .
  4. ↑ Executive Board of the GSCN. Retrieved January 23, 2020 .
  5. ^ Board of Directors - NCT National Center for Tumor Diseases Heidelberg. Retrieved January 23, 2020 .
  6. ↑ EACR Board | The European Association for Cancer Research. Retrieved February 17, 2020 .
  7. ↑ Irène Baccelli, Andreas Schneeweiss, Sabine Riethdorf, Albrecht Stenzinger, Anja Schillert: Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay . In: Nature Biotechnology . tape 31 , no. June 6 , 2013, ISSN  1087-0156 , p. 539-544 , doi : 10.1038 / nbt.2576 ( nature.com [accessed January 23, 2020]).
  8. ↑ Elisa M Noll, Christian Eisen, Albrecht Stenzinger, Elisa Espinet, Alexander Muckenhuber: CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma . In: Nature Medicine . tape 22 , no. 3 , March 2016, ISSN  1078-8956 , p. 278-287 , doi : 10.1038 / nm.4038 , PMID 26855150 , PMC 4780258 (free full text).
  9. ↑ Simon Raffel, Mattia Falcone, Niclas Kneisel, Jenny Hansson, Wei Wang: BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation . In: Nature . tape 551 , no. 7680 , November 2017, ISSN  0028-0836 , p. 384–388 , doi : 10.1038 / nature24294 ( nature.com [accessed January 23, 2020]).
  10. ↑ Carsten Bahr, Lisa von Paleske, Veli V. Uslu, Silvia Remeseiro, Naoya Takayama: A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies . In: Nature . tape 553 , no. 7689 , January 2018, ISSN  0028-0836 , p. 515-520 , doi : 10.1038 / nature25193 ( nature.com [accessed February 17, 2020]).
  11. ↑ Anna M. Paczulla, Kathrin Rothfelder, Simon Raffel, Martina Konantz, Julia Steinbacher: Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion . In: Nature . tape 572 , no. 7768 , August 2019, ISSN  0028-0836 , p. 254-259 , doi : 10.1038 / s41586-019-1410-1 , PMID 31316209 , PMC 6934414 (free full text).
  12. ↑ German Cancer Prize for excellent clinical, translational and experimental research - German Cancer Society. Retrieved February 19, 2020 .
  13. ↑ State Research Prize 2018 awarded. Retrieved January 23, 2020 .
  14. ↑ Swiss Bridge Award for research into breast cancer stem cells. Retrieved January 23, 2020 .
  15. ^ Past Award Recipients - International Society for Experimental Hematology. Retrieved January 23, 2020 .
  16. ↑ Andreas Trumpp recognized as Highly Cited Researcher 2019. Accessed January 23, 2020 (British English).
personal data
SURNAME Trumpp, Andreas
BRIEF DESCRIPTION German biologist and cancer researcher
DATE OF BIRTH March 6, 1964
PLACE OF BIRTH Heilbronn