Angelica Amon

Angelika Amon (2017)

Angelika B. Weis-Amon (born January 10, 1967 in Vienna ; † October 29, 2020 ) was an Austrian biologist who dealt with genetics and cell biology .

Life

Amon studied at the University of Vienna with a diploma in 1989 and a doctorate in 1993 with Kim Nasmyth at the Research Institute for Molecular Pathology (IMP). As a post-doctoral student , she was at the Whitehead Institute for Biomedical Research at the Massachusetts Institute of Technology (MIT). She became Assistant Professor and then Associate Professor at MIT's Koch Institute for Integrative Cancer Research , before joining MIT's Howard Hughes Medical Institute (HHMI) in 2000 , where she was Professor from 2007. From 2011 she held the Kathleen and Curtis Marble Chair in Cancer Research.

Amon studied the division of chromosomes during cell division ( meiosis and mitosis ) in the body and diseases that are related to disorders ( aneuploidy ) of the normal even distribution of chromosomes among the daughter cells. They are both a common cause of miscarriages and a hallmark of cancer cells. For her investigations of the molecular mechanisms involved, she used yeast cells and mouse cells (MEF, Mouse Embryotic Fibroblasts). In particular, she found that aneuploidy is often associated with overproduction of the body's own proteins, which clump together (due to special cell biological activities of the malevolent cells in response to the protein overproduction, which she called aneuploidy stress reaction ) and to neurodegenerative phenomena similar to those in Alzheimer's disease being able to lead. She studied in detail the mechanism by which the final stages of cell division are regulated, with the phosphatase CDC14 playing a central role, as Amon and colleagues found in 1998.

She was married and had two daughters.

Angelika Amon succumbed to on October 29, 2020 of cancer .

Awards (selection)

2000 HHMI Investigator Award
2003 Eli Lilly and Company-Elanco Research Award
2008 NAS Award in Molecular Biology
2010 member of the National Academy of Sciences
2013 Ernst Jung Prize , together with Ivan Dikic
2014 Genetics Society of America Medal
2015 Associate member of the European Molecular Biology Organization
2015 Corresponding member of the Austrian Academy of Sciences
2017 member of the American Academy of Arts and Sciences
2019 Breakthrough Prize in Life Sciences
2020 HFSP Nakasone Award

Web links

Homepage at MIT

Individual evidence

↑ 206. (WO2010147663) Methods and Compositions for Inhibiting Proliferation of Aneuploid Cells. In: patentscope.wipo.int . Retrieved October 30, 2020 .
↑ Austrian cancer researcher Angelika Amon died at the age of 53. In: DiePresse.com . October 29, 2020, accessed October 30, 2020 .
↑ R. Visintin, K. Craig, ES Hwang, S. Prinz, M. Tyers, A. Amon: The phosphatase Cdc14 triggers mitotic exit by reversal of CDK-dependent phosphorylation . Mol. Cell 2 (1998), pp. 709-718.
↑ Angelika Amon (1967 to 2020). IMP Research Institute of Molecular Pathology, October 29, 2020, accessed October 30, 2020 .
^ Eli Lilly and Company-Elanco Research Award Past Laureates. In: asm.org . Archived from the original on November 13, 2012 ; accessed on October 30, 2020 (English).
^ NAS Award in Molecular Biology. In: nasonline.org . Retrieved January 14, 2016 .
↑ Prize winner 2013: Research for Progress. Press release from the Ernst Jung Foundation. In: jung-stiftung.de. Archived from the original on March 9, 2013 ; accessed on October 30, 2020 .
^ Winners of the 2019 Breakthrough Prize in Life Sciences, Fundamental Physics and Mathematics Announced. In: breakthroughprize.org. October 17, 2018, accessed October 17, 2018 .

personal data
SURNAME	Amon, Angelica
ALTERNATIVE NAMES	Amon, Angelika B .; Weis-Amon, Angelika B.
SHORT DESCRIPTION	Austrian biologist
DATE OF BIRTH	January 10, 1967
PLACE OF BIRTH	Vienna
DATE OF DEATH	October 29, 2020

[1] 206. (WO2010147663) Methods and Compositions for Inhibiting Proliferation of Aneuploid Cells. In: patentscope.wipo.int . Retrieved October 30, 2020 .

[2] Austrian cancer researcher Angelika Amon died at the age of 53. In: DiePresse.com . October 29, 2020, accessed October 30, 2020 .

[3] R. Visintin, K. Craig, ES Hwang, S. Prinz, M. Tyers, A. Amon: The phosphatase Cdc14 triggers mitotic exit by reversal of CDK-dependent phosphorylation . Mol. Cell 2 (1998), pp. 709-718.

[4] Angelika Amon (1967 to 2020). IMP Research Institute of Molecular Pathology, October 29, 2020, accessed October 30, 2020 .

[5] Eli Lilly and Company-Elanco Research Award Past Laureates. In: asm.org . Archived from the original on November 13, 2012 ; accessed on October 30, 2020 (English).

[6] NAS Award in Molecular Biology. In: nasonline.org . Retrieved January 14, 2016 .

[7] Prize winner 2013: Research for Progress. Press release from the Ernst Jung Foundation. In: jung-stiftung.de. Archived from the original on March 9, 2013 ; accessed on October 30, 2020 .

[8] Winners of the 2019 Breakthrough Prize in Life Sciences, Fundamental Physics and Mathematics Announced. In: breakthroughprize.org. October 17, 2018, accessed October 17, 2018 .