Bas Congo Virus
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| Bas-Congo tibrovirus | ||||||||||||||||||||
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| BASV | ||||||||||||||||||||
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The Bas-Congo-Virus ( BASV ) is a pathogen from the Rhabdoviridae family associated with three cases of hemorrhagic fever that occurred in 2009 . The diseases occurred in Mangala in the Democratic Republic of the Congo and were characterized by a brilliant course. Two of the three patients died; antibodies against BASV were detected in the survivor and a fourth contact person who was not affected .
discovery
The virus was discovered after the known pathogens of hemorrhagic fever were excluded. In the serum of patients surviving BASV was in the form of RNA found -copies; the genome was largely reconstructed using deep sequencing . According to pedigree analyzes, BASV differs significantly from other known rhabdoviruses.
Above all, the fact that the infection with BASV apparently leads to hemorrhagic fever in humans is regarded as unusual , a clinical picture that had not previously occurred in humans in connection with rhabdoviruses. However, viral hemorrhagic septicemia is known in fish , a disease caused by viruses of the genus Novirhabdovirus that is associated with bleeding . So far, the various representatives of the genus Lyssavirus , which cause the disease pattern of rabies , have primarily been relevant for humans .
Course of disease and transmission
The disease associated with the Bas-Congo virus in humans is characterized by an acute, severe course. However, there is also evidence that infections can be asymptomatic. The disease sets in suddenly; Symptoms include high fever , nausea , vomiting , diarrhea , abdominal pain, headache, and exhaustion. Bleeding occurs very quickly (bleeding from the nose and gums, vomiting blood, bloody diarrhea). One patient showed eye bleeding. The two deceased patients died two or three days after the onset of symptoms, in both cases from circulatory failure. A third infected survived the disease.
The two first infected were students who had no proven personal contact with each other in the days before the illness, the source of the primary infection is unknown. The third sufferer was a nurse who looked after the two students until they died. This suggests that BASV is transmitted through close contact through body fluids; transmission through droplet infection would likely have resulted in greater spread. A fourth contact had antibodies against BASV but did not become ill.
Individual evidence
- ↑ ICTV Master Species List 2018b v1 MSL # 34, Feb. 2019
- ↑ a b ICTV: ICTV Taxonomy history: Akabane orthobunyavirus , EC 51, Berlin, Germany, July 2019; Email ratification March 2020 (MSL # 35)
- ↑ G. Grard, et al. : A Novel Rhabdovirus Associated with Acute Hemorrhagic Fever in Central Africa . In: PLoS Pathogens . 8, No. 9, 2012, p. E1002924. doi : 10.1371 / journal.ppat.1002924 .
