Benzothiophene
Structural formula | ||||||||||||||||
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General | ||||||||||||||||
Surname | Benzothiophene | |||||||||||||||
other names |
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Molecular formula | C 8 H 6 S | |||||||||||||||
Brief description |
white, flammable solid with an unpleasant odor |
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External identifiers / databases | ||||||||||||||||
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properties | ||||||||||||||||
Molar mass | 134.20 g mol −1 | |||||||||||||||
Physical state |
firmly |
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density |
1.1486 g cm −3 (36 ° C ) |
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Melting point |
28-32 ° C |
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boiling point |
222 ° C |
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Vapor pressure |
1.33 h Pa (20 ° C) |
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solubility |
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Refractive index |
1.6374 (37 ° C) |
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safety instructions | ||||||||||||||||
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Toxicological data | ||||||||||||||||
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C |
Benzothiophene is a chemical compound whose structure consists of a thiophene ring and a fused benzene ring . This bicyclic heteroaromatic is the basic structure of many derivatives for a wide range of applications in the chemical industry, especially in the pharmaceutical and dye industry, such as for example for insecticides, pesticides, thioindigo and pharmaceuticals such as raloxifene , zileuton and sertaconazole .
Occurrence
Benzothiophene naturally occurs in small quantities in petroleum, heating and heavy oils.
properties
Benzothiophene is a white, flammable solid with an unpleasant odor, which is sparingly soluble in water. It has a refractive index of 1.63 (at 37 ° C). In medicinal chemistry, benzothiophene isostere can be replaced by naphthalene.
Related links
- 2-benzothiophene , a structural isomer of 1-benzothiophene
- Methylbenzothiophene
- Dimethylbenzothiophene
- Trimethylbenzothiophene
- Dibenzothiophene
- Naphthobenzothiophene
Individual evidence
- ↑ a b c d e f Entry on thionaphthene in the GESTIS substance database of the IFA , accessed on February 14, 2017(JavaScript required) .
- ↑ a b Brockhaus ABC Chemie , VEB FA Brockhaus Verlag, Leipzig 1965, p. 1411.
- ↑ a b Benzothiophene data sheet (PDF) from Merck , accessed on January 18, 2011.
- ↑ David R. Lide (Ed.): CRC Handbook of Chemistry and Physics . 90th edition. (Internet version: 2010), CRC Press / Taylor and Francis, Boca Raton, FL, Physical Constants of Organic Compounds, pp. 3-40.