Bernard L. Strehler

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Bernard Louis Strehler (born February 21, 1925 in Johnstown , Cambria County , Pennsylvania , † May 3, 2001 in Agoura Hills , California ) was an American biologist and gerontologist .

Career and work

Strehler studied biology at Johns Hopkins University , where he graduated in 1947 . Three years later he also received his doctorate there . Then worked at the Oak Ridge National Laboratory in Tennessee . He identified luciferin , the fluorescent substance of various species of beetles, which he isolated from thousands of fireflies . Along with William Arnold spotted chaser that all green plants, as a result of the reversal of the first enzymatic step of photosynthesis , bioluminescent are. In 1952 he discovered that plants build up adenosine triphosphate in chloroplasts under the influence of light . Strehler later became an assistant professor in biochemistry at the University of Chicago . In 1956 he went to the National Institutes of Health , where he worked at the Gerontology Center in Baltimore . The University of Southern California (USC) appointed him Professor of Biology in 1967. He stayed at USC until his retirement in 1990. From 1960 on, Strehler focused primarily on biogerontological topics. He discovered that part of the ribosomal DNA in post- mitotic cells is lost to the cells over time. He noticed that the loss of human cells is seven times slower than that of domestic dog cells . The factor seven is also found in the two maximum life spans of both species.

Strehler was considered one of the most prominent gerontologists of his time. Over 250 publications bear his name. He died of a stroke in a nursing home. He left two daughters and a son. His wife Theodora died three years before him.

Books

literature

  • A. Bürkle: In memoriam Bernard Strehler - genomic instability in aging: a persistent challenge. In: Mech Aging Dev 123, 2002, pp. 899-906. PMID 12044938
  • CE Finch: Bernard Strehler - inspiration for basic research into the mechanisms of aging. In: Mech Aging Dev. 123, 2002, pp. 827-829. PMID 12044930

Individual evidence

  1. ^ WD McElroy and BL Strehler: Factors influencing the response of the bioluminescent reaction to adenosine triphosphate. In: Arch Biochem. 22, 1949, pp. 420-433. PMID 18134550
  2. ^ WD McElroy and BL Strehler: Purification of firefly luciferin. In: J Cell Physiol . 34, 1949, pp. 457-466. PMID 15406363
  3. ^ BL Strehler: The luminescence of isolated chloroplasts. In: Arch Biochem. 34, 1951, pp. 239-248. PMID 14904058
  4. ↑ BL Strehler: The isolation and properties of firefly luciferesceine. In: Arch Biochem. 32, 1951, pp. 397-406. PMID 14857762
  5. ↑ BL Strehler and MP Chang: Loss of hybridizable ribosomal DNA from human post-mitotic tissues during aging: II. Age-dependent loss in human cerebral cortex - hippocampal and somatosensory cortex comparison. In: Mech Aging Dev. 11, 1979, pp. 379-382. PMID 529838
  6. ↑ BL Strehler et al.: Loss of hybridizable ribosomal DNA from human post-mitotic tissues during aging: I. Age-dependent loss in human myocardium. In: Mech Aging Dev. 11, 1979, pp. 371-378. PMID 529837
  7. ^ R. Johnson and BL Strehler: Loss of genes coding for ribosomal RNA in aging brain cells. In: Nature . 240, 1972, pp. 412-414. PMID 4564320
  8. ^ Obituary for Bernard Strehler, USC Professor of Biology; Studied aging. Retrieved September 14, 2010
  9. ↑ LS Coles: The life and contributions of Professor Bernard L. Strehler, founding editor-in-chief of mechanisms of aging and development, professor of biology at the University of Southern California (February 21, 1925-May 13, 2001). In: Mech Aging Dev. 123, 2002, pp. 821-825. PMID 12044929
personal data
SURNAME Strehler, Bernard
ALTERNATIVE NAMES Strehler, Bernard Louis
BRIEF DESCRIPTION American biologist and gerontologist
DATE OF BIRTH February 21, 1925
PLACE OF BIRTH Johnstown , Pennsylvania
DATE OF DEATH May 3, 2001
Place of death Agoura Hills , California