Carboplatin

Structural formula
General
Non-proprietary name	Carboplatin
other names	Diammine platinum (II) cyclobutane 1,1-dicarboxylate
Molecular formula	C 6 H 12 N 2 O 4 Pt
External identifiers / databases
EC number	255-446-0
ECHA InfoCard	100.050.388
PubChem	10339178
DrugBank	DB00958
Wikidata	Q415588
Drug information
ATC code	L01 XA02
Drug class	Cytostatics
properties
Molar mass	371.25 g mol −1
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
H and P phrases	H: 302-312-317-332-334-360
	P: 201-261-280-308 + 313
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Carboplatin is a very common cytostatic drug (used to fight cancer ). The chemical structure contains a complex bonded platinum atom , it is a cisplatin derivative. The effect against cancer cells is based on a cross-linking of the DNA molecules (genetic material), which thereby become inoperable. The cell metabolism is hindered and the cell dies. Like other cytostatic agents, carboplatin acts in this way not only on rapidly growing tumor cells , but to a certain extent also on healthy body cells. It is given intravenously.

Mechanism of resistance

Note the cross-resistance with cisplatin .

indication

Application areas for carboplatin are bronchial carcinoma , ovarian carcinoma , breast carcinoma and testicular cancer . Carboplatin is administered as an infusion within 15 to 60 minutes, usually at intervals of 4 weeks, and is used almost exclusively in combination with other chemotherapeutic agents (combination chemotherapy ). A combination of newer cytostatic agents such as gemcitabine , vinorelbine or taxanes with the platinum salts cisplatin or carboplatin has established itself as the standard therapy worldwide.

unwanted effects

Vomiting (therefore often simultaneous administration of antiemetics ), hearing damage or ringing in the ears ( tinnitus ), dizziness , allergies , nerve damage, abdominal pain , constipation, diarrhea , damage to blood-forming cells of the bone marrow . In addition, carboplatin is nephrotoxic (it damages the kidneys ).