Carboplatin
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Non-proprietary name | Carboplatin | ||||||||||||||||||
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Diammine platinum (II) cyclobutane 1,1-dicarboxylate |
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Molecular formula | C 6 H 12 N 2 O 4 Pt | ||||||||||||||||||
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properties | |||||||||||||||||||
Molar mass | 371.25 g mol −1 | ||||||||||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Carboplatin is a very common cytostatic drug (used to fight cancer ). The chemical structure contains a complex bonded platinum atom , it is a cisplatin derivative. The effect against cancer cells is based on a cross-linking of the DNA molecules (genetic material), which thereby become inoperable. The cell metabolism is hindered and the cell dies. Like other cytostatic agents, carboplatin acts in this way not only on rapidly growing tumor cells , but to a certain extent also on healthy body cells. It is given intravenously.
Mechanism of resistance
Note the cross-resistance with cisplatin .
indication
Application areas for carboplatin are bronchial carcinoma , ovarian carcinoma , breast carcinoma and testicular cancer . Carboplatin is administered as an infusion within 15 to 60 minutes, usually at intervals of 4 weeks, and is used almost exclusively in combination with other chemotherapeutic agents (combination chemotherapy ). A combination of newer cytostatic agents such as gemcitabine , vinorelbine or taxanes with the platinum salts cisplatin or carboplatin has established itself as the standard therapy worldwide.
unwanted effects
Vomiting (therefore often simultaneous administration of antiemetics ), hearing damage or ringing in the ears ( tinnitus ), dizziness , allergies , nerve damage, abdominal pain , constipation, diarrhea , damage to blood-forming cells of the bone marrow . In addition, carboplatin is nephrotoxic (it damages the kidneys ).
Trade names
Axicarb (D), Carbo-cell (D), Carbomedac (D), Haemato-carb (D), Neocarbo (D), Paraplatin (CH), Ribocarbo (D), various generics (D, A, CH)
Web links
Individual evidence
- ↑ a b Carboplatin data sheet from Sigma-Aldrich , accessed on March 15, 2011 ( PDF ).
- ↑ Single-dose carboplatin is just as effective in testicular cancer as radiotherapy .
- ↑ Cisplatin versus carboplatin in NSCLC in advanced stages ( Memento from September 29, 2007 in the Internet Archive ) (PDF; 56 kB).
- ↑ Red List online, as of September 2009.
- ↑ AM comp. d. Switzerland, as of September 2009.
- ↑ AGES-PharmMed, as of September 2009.