Carteolol

from Wikipedia, the free encyclopedia
Structural formula
Carteolol structural formula
1: 1 mixture of enantiomers ( racemate )
General
Non-proprietary name Carteolol
other names
  • ( RS ) -5- [2-Hydroxy-3- ( tert -butylamino) propoxy] -3,4-dihydro-1 H -quinolin-2-one
  • (±) -5- [2-hydroxy-3- ( tert -butylamino) propoxy] -3,4-dihydro-1 H -quinolin-2-one
  • 5- (3- tert -butylamino-2-hydroxypropoxy) -3,4-dihydro-2 (1 H ) -quinolinone
Molecular formula
Brief description

white crystalline powder

External identifiers / databases
CAS number
  • 51781-06-7
  • 51781-21-6 (hydrochloride)
PubChem 2583
ChemSpider 2485
DrugBank DB00521
Wikidata Q546434
Drug information
ATC code
Drug class

Beta blockers

Mechanism of action

Inhibition of the β 1 - and β 2 - adrenoceptors

properties
Molar mass 292.4 g · mol -1
Physical state

firmly

Melting point

278 ° C (hydrochloride)

solubility
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances

Hydrochloride

07 - Warning 08 - Dangerous to health

danger

H and P phrases H: 302-361fd
P: 201-264-270-280-308 + 313-405
Toxicological data

1330 mg kg −1 ( LD 50 ,  rat ,  oral , hydrochloride)

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Carteolol is a drug from the group of non-selective beta blockers with intrinsic sympathomimetic activity. By acting on the cardiac β 1 - and β 2 -receptors, Carteolol lowers the beat rate and the contraction force of the heart, the AV conduction velocity and the plasma renin activity. It is therefore indicated for the treatment of cardiac arrhythmias and angina pectoris .

The active ingredient was patented by Otsuka Pharmaceutical in 1973 .

Carteolol further lowers the intraocular pressure by decreasing the production of aqueous humor and in the treatment of glaucoma used. The exact mechanism of action is not known.

Trade names

Individual evidence

  1. ↑ Entry on Carteolol in Pharmawiki , accessed on January 28, 2017.
  2. ^ The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals , 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006; P. 304, ISBN 978-0-911910-00-1 .
  3. ↑ a b c d e f Entry on Carteolol at TCI Europe, accessed on December 21, 2019.
  4. ↑ Entry on Carteolol. In: Römpp Online . Georg Thieme Verlag, accessed on May 19, 2015.