Cefacedon

Structural formula
General
Non-proprietary name	Cefacedon
other names	7- {2- [3,5-dichloro-4-oxo-1 (4 H ) -pyridyl] -acetamido} -3- (5-methyl-1,3,4-thiadiazol-2-ylthiomethyl) -3- cephem-4-carboxylic acid ( IUPAC )
Molecular formula	C 18 H 15 Cl 2 N 5 O 5 S 3
Brief description	white to yellowish white powder
External identifiers / databases
EC number	611-363-5
ECHA InfoCard	100.121.805
PubChem	71736
ChemSpider	64780
DrugBank	DB13778
Wikidata	Q5057222
Drug information
ATC code	J01 DB06
Drug class	β-lactam antibiotic; 1st generation cephalosporins;
Mechanism of action	Disturbance of cell wall synthesis
properties
Molar mass	548.43 g · mol -1
Physical state	firmly
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
H and P phrases	H: 302-361-410
	P: 273-281
Toxicological data	6800 mg kg −1 ( LD 50 , mouse , iv )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Cefacedon is an antibiotic that is used to treat bacterial infections. It is produced semisynthetically and belongs to the class of cephalosporins of the 1st generation.

Cefazedon was first patented by Merck in 1975 . Medicines containing cefacedone (trade name Refosporin ) are no longer available in Germany.

indication

Cefazedon is indicated for the treatment of infections caused by sensitive pathogens (infections of the respiratory tract, urinary tract and biliary tract).

Working principle

The cefacedon molecules bind - like all cephalosporins - to specific penicillin-binding proteins , which are required to rebuild the bacterial cell wall. This prevents further synthesis of the bacterial cell wall.

Application

Cefazedon can be administered orally as well as intramuscularly and intravenously .

Individual evidence

↑ ^a ^b ^c ^d CEFAZEDONE. chemicalland21.com, accessed May 20, 2019 .
↑ ^a ^b bldpharm: SDS Cefazedon , accessed on December 27, 2019.
↑ ^a ^b Entry on Cefazedon. In: Römpp Online . Georg Thieme Verlag, accessed on May 22, 2019.
↑ Drug Update: Fluoroquinolones. German STI Society - Society for the Promotion of Sexual Health, accessed on May 20, 2019 .
↑ ^a ^b Conference Guide of the North Rhine-Westphalian Society for Urology, May 1981 , accessed on May 22, 2019.

[:0-1] CEFAZEDONE. chemicalland21.com, accessed May 20, 2019 .

[bldpharm-2] rm: SDS Cefazedon , accessed on December 27, 2019.

[Römpp-3] Entry on Cefazedon. In: Römpp Online . Georg Thieme Verlag, accessed on May 22, 2019.

[4] Drug Update: Fluoroquinolones. German STI Society - Society for the Promotion of Sexual Health, accessed on May 20, 2019 .

[refosporin-5] Conference Guide of the North Rhine-Westphalian Society for Urology, May 1981 , accessed on May 22, 2019.