Chlozolinate
Structural formula | ||||||||||||||||
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Structural formula of the isomer mixture without specifying the stereochemistry | ||||||||||||||||
General | ||||||||||||||||
Surname | Chlozolinate | |||||||||||||||
other names |
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Molecular formula | C 13 H 11 Cl 2 NO 5 | |||||||||||||||
Brief description |
colorless solid |
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External identifiers / databases | ||||||||||||||||
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properties | ||||||||||||||||
Molar mass | 332.14 g mol −1 | |||||||||||||||
Physical state |
firmly |
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density |
1.44 g cm −3 |
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Melting point |
113-114 ° C |
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solubility |
practically insoluble in water (0.032 g l −1 at 20 ° C) |
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safety instructions | ||||||||||||||||
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Toxicological data | ||||||||||||||||
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Chlozolinate is a chemical compound from the group of dicarboximides .
Extraction and presentation
Chlozolinate can be obtained by reaction of phosgene with 3,5-dichloroaniline and subsequent reaction with diethylmethyltartronic acid ester.
Use and approval
Chlozolinate was used as a fungicide. The effect is based on the inhibition of the MAP kinase pathway in the signal chain.
In 2000, the EU Commission decided not to include chlozolinate in the list of permitted active ingredients in pesticides.
In Germany, Austria and Switzerland, no pesticides with this active ingredient are permitted.
Individual evidence
- ↑ a b c Entry on chlozolinate in the Pesticide Properties DataBase (PPDB) of the University of Hertfordshire , accessed on September 9, 2013.
- ↑ a b c Ash: Handbook of Preservatives . Synapse, 2004, ISBN 1-890595-66-7 , pp. 332 ( limited preview in Google Book search).
- ↑ Entry on chlozolinate in the GESTIS substance database of the IFA , accessed on July 23, 2016(JavaScript required) .
- ↑ Entry on Ethyl (RS) -3- (3,5-dichlorophenyl) -5-methyl-2,4-dioxooxazolidine-5-carboxylate in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on August 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .
- ↑ Data sheet Chlozolinate solution, 100 ng / μL in cyclohexane, PESTANAL at Sigma-Aldrich , accessed on May 19, 2017 ( PDF ).
- ↑ Thomas A. Unger: Pesticide Synthesis Handbook . William Andrew, 1996, ISBN 0-8155-1853-6 , pp. 487 ( limited preview in Google Book search).
- ↑ Decision of the Commission of October 13, 2000 (PDF) on the non-inclusion of chlozolinate in Annex I of Directive 91/414 / EEC and the revocation of the approvals for plant protection products with this active substance (2000/626 / EC).
- ↑ General Directorate Health and Food Safety of the European Commission: Entry on Chlozolinate in the EU pesticide database; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; accessed on February 23, 2016.