Corticosterone

Structural formula
General
Surname	Corticosterone
other names	11 β , 21-dihydroxy-pregn-4-en-3,20-dione; Reichstein's substance H; Kendall's substance B;
Molecular formula	C 21 H 30 O 4
Brief description	colorless, trigonal plates
External identifiers / databases
EC number	200-019-6
ECHA InfoCard	100,000,018
PubChem	5753
ChemSpider	5550
DrugBank	DB04652
Wikidata	Q422543
properties
Molar mass	346.45 g mol −1
Physical state	firmly
Melting point	181 ° C
solubility	little in water (199 mg l −1 at 25 ° C)
safety instructions
GHS labeling of hazardous substances Caution
H and P phrases	H: 317
	P: 280
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Corticosterone , and corticosterone , 1937 is a first time of Tadeusz Reichstein isolated derivative of the pregnane (C ₂₁ - Steroid ) and is referred to as steroid hormone in the adrenal cortex ( Cortex formed of the adrenal gland).

effect

Corticosterone is involved in the metabolism of carbohydrates, sodium and potassium. It is also necessary for the absorption and storage of glucose .

In many species, including rodents , corticosterone is the most important glucocorticoid .

In humans, on the other hand, it has only a weak glucocorticoid and mineralocorticoid effect. Above all, it is one of the intermediate products of the steroid synthesis from pregnenolone to aldosterone .

biosynthesis

Corticosterone is in the adrenal cortex of progesterone by double hydroxylation ( 21-hydroxylase and 11 β -hydroxylase formed).

Individual evidence

↑ Entry on corticosterone. In: Römpp Online . Georg Thieme Verlag, accessed on June 21, 2014.
↑ ^a ^b Entry on corticosterone in the ChemIDplus database of the United States National Library of Medicine (NLM) .
↑ ^a ^b data sheet corticosterone from Sigma-Aldrich , accessed on March 23, 2011 ( PDF ).
↑ Lois Jovanovic, Genell J. Subak-Sharpe: Hormones. The medical manual for women. (Original edition: Hormones. The Woman's Answerbook. Atheneum, New York 1987) From the American by Margaret Auer, Kabel, Hamburg 1989, ISBN 3-8225-0100-X , pp. 28 and 379.

[Römpp-1] Entry on corticosterone. In: Römpp Online . Georg Thieme Verlag, accessed on June 21, 2014.

[ChemIDplus-2] Entry on corticosterone in the ChemIDplus database of the United States National Library of Medicine (NLM) .

[Sigma-3] ta sheet corticosterone from Sigma-Aldrich , accessed on March 23, 2011 ( PDF ).

[4] Lois Jovanovic, Genell J. Subak-Sharpe: Hormones. The medical manual for women. (Original edition: Hormones. The Woman's Answerbook. Atheneum, New York 1987) From the American by Margaret Auer, Kabel, Hamburg 1989, ISBN 3-8225-0100-X , pp. 28 and 379.