Craig B. Thompson

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Craig B. Thompson

Craig B. Thompson (* 1953 ) is an American immunologist , oncologist, and cancer researcher at the Memorial Sloan-Kettering Cancer Center in New York City .

Life

Thompson earned a bachelor's degree from Dartmouth College and then studied at the University of Pennsylvania medicine, in 1977 he graduated with an MD . He completed his training as an internal medicine specialist at Harvard Medical School and the Fred Hutchinson Cancer Research Institute at the University of Washington . He then worked at the National Naval Medical Center in Bethesda , Maryland and at the same time received a first professorship (Assistant Professor) at the Uniformed Services University of the Health Sciences there . In 1987 Thompson moved to the University of Michigan as Assistant Professor of Internal Medicine , and in 1993 as Full Professor at the University of Chicago , where he headed the Gwen Knapp Center for Lupus and Immunology Research .

From 1987 to 1999, Thompson also conducted research for the Howard Hughes Medical Institute . From 1999 to 2010 he was a professor at the University of Pennsylvania , where he initially headed the Research Institute for familial cancer and from 2006 took over the management of the Abramson Cancer Center there .

Since 2010, Thompson has served as President of the Memorial Sloan-Kettering Cancer Center in New York City . His wife Tullia Lindsten also works there as a cancer researcher.

Act

Thompson conducts basic research in cancer biology and immunology. His pioneering work contributed to the development of novel drugs for the treatment of autoimmune diseases , transplant rejection , cancer and AIDS .

Thompson was able to show that CD28 regulates the production of cytokines , the survival of lymphocytes and the homeostasis of the immune system . Thompson and co-workers identified CTLA-4 as a negative regulator of CD28 activation. Other discoveries by Thompson include: gene conversion as a mechanism for the diversification of immunoglobulins (at least in birds), addition of phosphorylated nucleotides in V (D) J recombination , channel-forming properties of Bcl-2 proteins and their role in the regulation of mitochondria - Function, the role of Bax and Bak in apoptosis . Current work deals with signal transduction for the regulation of nutrient uptake into the cell and its importance for cell growth and survival.

Thompson is (as of 2016) the author of more than 350 peer-reviewed papers and more than 85 systematic reviews . Since 2016 Thomson Reuters has counted him among the favorites for a Nobel Prize ( Thomson Reuters Citation Laureates ) due to the number of his citations .

Awards (selection)

Web links

Individual evidence

  1. ^ Craig B. Thompson, MD - HHMI.org. In: hhmi.org. Retrieved September 26, 2016 .
  2. ↑ Web of Science Predicts 2016 Nobel Prize Winners. (No longer available online.) In: ipscience.thomsonreuters.com. September 21, 2016, archived from the original on September 21, 2016 ; accessed on September 26, 2016 (English).
  3. ↑ Book of Members 1780 – present (PDF, 693 kB) of the American Academy of Arts and Sciences In: amacad.org; Retrieved September 26, 2016.
  4. ^ The American Society for Clinical Investigation. In: the-asci.org. Retrieved September 26, 2016 .
  5. ↑ Craig Thompson. In: nasonline.org. Retrieved September 26, 2016 .
personal data
SURNAME Thompson, Craig B.
BRIEF DESCRIPTION American immunologist, oncologist, and cancer researcher
DATE OF BIRTH 1953