Febuprol

Structural formula
	( R ) shape (top) and ( S ) shape (bottom)
General
Non-proprietary name	Febuprol
other names	( RS ) -1-butoxy-3-phenoxypropan-2-ol ( IUPAC )
Molecular formula	C 13 H 20 O 3
Brief description	colorless oil
External identifiers / databases
EC number	221-454-8
ECHA InfoCard	100.019.504
PubChem	71119
ChemSpider	64270
Wikidata	Q1399406
Drug information
ATC code	A05 AX09
Drug class	Choleretic
properties
Molar mass	224.30 g · mol -1
density	1.027 g cm −3
boiling point	165 ° C (1.466 k Pa ); 125 - 132 ° C (133.3 Pa)
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling ; no classification available
Toxicological data	3050 mg kg −1 ( LD 50 , mouse , oral ) ; 436 mg kg −1 ( LD 50 , mouse , ip ) ; 2370 mg kg −1 ( LD 50 , rat , oral ) ; 436 mg kg −1 ( LD 50 , rat , ip ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Febuprol is a drug from the group of choleretics , that is, it stimulates bile secretion . It also has spasmolytic (antispasmodic) and lipid-lowering (blood lipid lowering) properties.

The drug has a stereocenter, so it is chiral and is present as a racemate [1: 1 mixture of the ( R ) isomer and the ( S ) isomer].

literature

U. Ritter u. HJ Kyrein: Clinical trial of febuprol, a new substance with choleretic activity. Study of efficacy and tolerability . In: Arzneimittelforschung , Vol. 33/6, 1983, pp. 891-897 (in German), PMID 6684447 .

^ The Merck Index : An Encyclopedia of Chemicals, Drugs, and Biologicals , 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006; P. 674, ISBN 978-0-911910-00-1 .
↑ ^a ^b Entry on Febuprol. In: Römpp Online . Georg Thieme Verlag, accessed on June 7, 2014.
↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
↑ ^a ^b ^c ^d A. Kleemann , J. Engel, B. Kutscher, D. Reichert: Pharmaceutical Substances - Synthesis, Patents, Applications , 4th edition (2000), Thieme-Verlag Stuttgart, ISBN 978-1-58890-031 -9 .

Valbil (D, except trade)