Fludrocortisone

from Wikipedia, the free encyclopedia
Structural formula
Structure of fludrocortisone
General
Non-proprietary name Fludrocortisone
other names

(8 S , 9 R , 10 S , 11 S , 13 S , 14 S , 17 R ) -9-fluoro-11,17-dihydroxy-17- (2-hydroxyacetyl) -10,13-dimethyl-1,2 , 6,7,8,11,12,14,15,16-decahydrocyclopenta [ a ] phenanthren-3-one

Molecular formula C 21 H 29 FO 5
External identifiers / databases
CAS number 127-31-1
EC number 204-833-2
ECHA InfoCard 100.004.395
PubChem 31378
ChemSpider 29111
DrugBank DB00687
Wikidata Q2697578
Drug information
ATC code

H02 AA02

Drug class

Mineralocorticoids

properties
Molar mass 380.45 g · mol -1
Physical state

firmly

Melting point

225 ° C

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Fludrocortisone is a synthetic aldosterone derivative whose effects are primarily mineralocorticoid , but also have a low glucocorticoid effect. It is used to treat primary adrenal insufficiency ( Addison's disease , congenital adrenal hyperplasia ).

Mechanism of action

The effects of fludrocortisone mainly come about through binding to mineralocorticoid receptors . Thus, in the renal reabsorption of sodium and - chloride - ions increased. In addition, the renal excretion of potassium , hydrogen and ammonium ions is increased. In addition, the glomerular filtration rate is also increased in the glomeruli . In addition, the water permeability of the distal tubules is reduced.

Pharmacokinetics

The active ingredient is by oral rapidly absorbed recording. The maximum plasma concentration is reached in humans after four to eight hours. Fludrocortisone is hydrolyzed in the liver and 80% is excreted through the kidneys and 20% with the stool. The plasma half-life is approximately 3.5 hours. The effects last for 12 to 36 hours.

Trade names

  • Florinef , Astonin-H

Web links

Individual evidence

  1. ↑ a b c Entry on fludrocortisone at Vetpharm, accessed on May 25, 2017.
  2. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.