Gerald Crabtree

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Gerald Rodney Crabtree (born December 18, 1946 ) is an American cell biologist .

life and work

Crabtree grew up on a small farm in Potrock Hollow, West Virginia . He studied chemistry and mathematics at West Liberty State College, West Liberty , where he received his bachelor's degree in 1968 . In 1972 he was at the Temple University Medical School for MD PhD . He later worked with Allan Munck on the biochemistry of steroids . From 1979 to 1982 he was Assistant Professor of Pathology at Dartmouth Medical School in Hanover . After two years at the National Institutes of Health , he became an adjunct professor of pathology at Stanford University's School of Medicine in 1985 . He has been Professor of Pathology and Developmental Biology there since 1993 and has also been doing research at the Howard Hughes Medical Institute since 1994 .

He studies the interaction between cells and their environment. In the 1980s he discovered the hepatocyte nuclear factor 1 and the nuclear factor of activated T cells ( NF-AT ) and was able to demonstrate the mechanism of action of ciclosporin . In the collaboration with Stuart Schreiber , which began in 1991 , he was able, among other things, to find the information transport path from cell membrane to cell nucleus , the calcium - calcineurin- NFAT pathway. This is important for bone development and insulin production. This opens up new treatments for diabetes and osteoporosis .

Publications

Crabtree has published more than 125 scientific papers.

Awards

  • 1984 NIH Director's Award
  • 1986 Warner Lambert Park Davis Award
  • 2004 Outstanding Inventor (Stanford University)
  • 2006 Thomas Scientific Laureate in Chemistry

Memberships

Individual evidence

  1. ↑ G. Courtois, JG Morgan, LA Campbell, G. Fourel and G. Crabtree: Interaction of a liver specific nuclear factor with the fibrinogen and alpha1 antitrypsin promoters . In: Science . Volume 238, 1987, pp. 688-690.
  2. ↑ EA Emmel, CL Verweij, DB Durand, KM Higgins, E. Lacy and GR Crabtree: Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation . In: Science . Volume 246, 1989, pp. 1617-1620.
  3. ↑ Stuart L. Schreiber and Gerald Crabtree: Immunophilins, Ligands, and the Control of Signal Transduction . In: Harvey Society Lectures . Volume 89, 1997, pp. 373-380.
  4. Jump up ↑ Monte M. Winslow, Minggui Pan, Michael Starbuck, Elena M. Gallo, Lei Deng, Gerard Karsenty and Gerald R. Crabtree: Calcineurin / NFAT Signaling in Osteoblasts Regulates Bone Mass . In: Developmental Cell . Volume 10, No. 6, 2006, pp. 771-782

Web links

personal data
SURNAME Crabtree, Gerald
ALTERNATIVE NAMES Crabtree, Gerald Rodney (full name)
BRIEF DESCRIPTION American cell biologist
DATE OF BIRTH December 18, 1946