Gerhard Schwarz (physicist)

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Gerhard Black (1989)

Gerhard Schwarz (born February 3, 1930 in Bremen ; † January 16, 2015 ) was a German physicist and co-founder of the Biozentrum of the University of Basel .

Life

Gerhard Schwarz studied from 1950 to 1955 at the Georg August University in Göttingen , where he obtained his doctorate in 1958 in the group of the later Nobel Prize winner Manfred Eigen . Interrupted by a stay as a postdoc from 1960 to 1962 at the University of Pennsylvania , he continued his work in his own working group at the Max Planck Institute for Biophysical Chemistry until 1969. After his habilitation in 1968 at the Technical University of Braunschweig , he was appointed to the chair for Biophysical Chemistry at the Biozentrum of the University of Basel in 1969 . Schwarz retired in 2000 .

Act

During his many years of research, Schwarz investigated the molecular mode of action of membrane-active substances. He was particularly interested in the interactions between peptides and proteins and lipid membranes based on physico-chemical principles . An important focus in Gerhard Schwarz's research was the development of kinetic measuring methods for the investigation of fast chemical processes. Furthermore, Schwarz developed a method, the so-called “mass conservation plot” approach, with which binding isotherms can be analyzed without a model and thermodynamic processes can be explained . His work provided significant insights into the molecular mechanisms of various membrane functions such as distribution equilibria , pore formation , antibiotic permeation and binding studies.

Awards

Publications

  • with Jürgen Engel: Kinetics of cooperative conformational transitions of linear biopolymers. In: Angewandte Chemie. Volume 84, Issue 13, 1972, pp. 615-623, doi : 10.1002 / anie.19720841303
  • with S. Stankowski Lipid dependence of peptide-membrane interactions. Bilayer affinity and aggregation of the peptide alamethicin. In: FEBS Lett. 250, 1989, pp. 556-560.
  • with U. Blochmann: Association of the wasp venom peptide mastoparan with electrically neutral lipid vesicles. Salt effects on partitioning and conformational state. In: FEBS Lett. 318, 1993, pp. 172-176.
  • with SE Taylor: The molecular area characteristics of the HIV-1 gp41-fusion peptide at the air / water interface. Effect of pH. In: Biochim Biophys Acta. 1326, 1997, pp. 257-264.
  • with N. Hellmann: Peptide-liposome association. A critical examination with mastoparan X. In: Biochim. Biophys. Acta. 1998, pp. 267-277.
  • A universal thermodynamic approach to analyze biomolecular binding experiments. In: Biophys. Chem. 86, 2000, pp. 119-129.

Web links

Individual evidence

  1. ^ Obituary for Gerhard Schwarz , unibas.ch, accessed on February 24, 2015
  2. ↑ The Biozentrum - its history and significance , unibas.ch, accessed on November 17, 2014
  3. ↑ Emeriti , unibas.ch, accessed on November 17, 2014.
  4. ^ Kinetic Analysis by Chemical Relaxation Methods , aps.org, accessed November 18, 2014
  5. ↑ Negative cooperativity and aggregation in biphasic binding of mastoparan X peptide to membranes with acidic lipids , sciencedirect.com, accessed November 18, 2014
  6. ↑ Nernst Haber Bodenstein Prize ( Memento of the original from October 22, 2015 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. , bunsen.ch, accessed on November 17, 2014  @1@ 2Template: Webachiv / IABot / www.bunsen.de
personal data
SURNAME Black, Gerhard
BRIEF DESCRIPTION German physicist
DATE OF BIRTH February 3, 1930
PLACE OF BIRTH Bremen
DATE OF DEATH January 16, 2015