Hepacivirus

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Hepacivirus
HCV particles.jpg

HCV virions from serum

Systematics
Classification : Viruses
Area : Riboviria
Empire : Orthornavirae
Phylum : Kitrinoviricota
Class : Flasuviricetes
Order : Amarillovirales
Family : Flaviviridae
Genre : Hepacivirus
Taxonomic characteristics
Genome : (+) ss RNA linear
Baltimore : Group 4
Cover : available
Scientific name
Hepacivirus
Left
NCBI  Taxonomy: 11102
ViralZone ( ExPASy , SIB): 37

Hepacivirus is a genus of single-stranded RNA viruses in the Flaviviridae family . The most important species is Hepacivirus C with the hepatitis C virus (HCV) discovered in 1989 , for which humans are the only known natural host and which can cause hepatitis C, hepatocellular carcinoma as well as malignant lymphoma .

The GB virus B (GBV-B), discovered in 1995, is able to infect New World monkeys , especially marmosets of the tamarine (Sanguini) tribe . Like HCV, it is blood-borne and similar to HCV and is associated with viral hepatitis. However, GBV-B has never been detected in wild animals and its natural host is therefore unknown.

Systematics

The viruses of this genus are currently divided into 14 species:

  • Genus Hepacivirus
    • Species Hepacivirus A
      • Canine hepacivirus
      • Non-primate hepacivirus
      • Equine hepacivirus
    • Species Hepacivirus B
    • Species Hepacivirus C
      • Hepatitis C virus
    • Species Hepacivirus D
      • Guereza hepacivirus
    • Species Hepacivirus E
      • Rodent Hepacivirus-339
    • Species Hepacivirus F
      • Rodent Hepacivirus NLR07-Oct70
    • Species Hepacivirus G
      • Norway rat hepacivirus 1
    • Species Hepacivirus H
      • Norway rat hepacivirus 2
    • Species Hepacivirus I
      • Rodent Hepacivirus SAR-3 / RSA / 2008
    • Species Hepacivirus J
      • Rodent Hepacivirus RMU10-3382 / GER / 2010
    • Species Hepacivirus K
      • Asked Hepacivirus PDB-829
    • Species Hepacivirus L
      • Asked Hepacivirus PDB-112
    • Species Hepacivirus M
      • Bat Hepacivirus PDB-491.1
    • Species Hepacivirus N
      • Bovine hepacivirus
not confirmed by ICTV are according to NCBI u. a.
    • Species " Hepacivirus P ", host: human
    • Species " Chinese broad-headed pond turtle hepacivirus "
    • Species " Chinese softshell turtle hepacivirus "
    • Species " Guangxi chinese leopard gecko hepacivirus Guangxi "
    • Species " Hainan oriental leaf-toed gecko hepacivirus "
    • Species " Western African lungfish hepacivirus "
    • Species " Wenling moray eel hepacivirus "
    • Species " Nanhai dogfish shark hepacivirus "
    • Species " Nanhai ghost shark hepacivirus 1 "
    • Species " Nanhai ghost shark hepacivirus 2 "
    • Species " Wenling shark virus " (WLSV), attacks the graceful dogfish ( Proscyllium habereri , English graceful catshark )
    • Species " Xiamen sepia Stingray hepacivirus " attacks the stingrays Urolophus aurantiacus
    • Species " Xiamen guitarfish hepacivirus ", attacks guitar rays (Rhinobatidae)

Individual evidence

  1. ↑ ICTV Master Species List 2018b.v2 . MSL # 34, March 2019
  2. ↑ a b c d ICTV Taxonomy history: Yellow fever virus . ICTV, EC 51, Berlin, July 2019; Email ratification March 2020 (MSL # 35)
  3. ↑ a b c Flaviviridae ( en )
  4. ↑ a b J. T Stapleton, S Foung, A. S Muerhoff, J Bukh, P Simmonds: The GB viruses: A review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae . In: Journal of General Virology . 92, No. 2, 2010, pp. 233-46. doi : 10.1099 / vir.0.027490-0 . PMID 21084497 . PMC 3081076 (free full text).
  5. ↑ Viral Zone . ExPASy. Retrieved December 11, 2018.
  6. ↑ Donald B Smith, Paul Becher, Jens Bukh, Ernest A Gould, Gregor Meyers, Thomas Monath, A. Scott Muerhoff, Alexander Pletnev, Rebecca Rico-Hesse, Jack T Stapleton, Peter Simmonds: Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the Flaviviridae family . In: Journal of General Virology . 97, No. 11, 2016, pp. 2894-2907. doi : 10.1099 / jgv.0.000612 . PMID 27692039 . PMC 5770844 (free full text).
  7. ↑ B. Beames, D. Chavez, RE Lanford: GB virus B as a model for hepatitis C virus . In: ILAR J. , 2001, 42 (2), pp. 152-160, PMID 11406717
  8. ↑ Unclassified Hepacivirus
  9. ^ Hepacivirus P (species) NCBI
  10. ↑ Chinese broad-headed pond turtle hepacivirus (species) NCBI
  11. ↑ Chinese softshell turtle hepacivirus (species) NCBI
  12. ↑ chinese leopard gecko hepacivirus (species) NCBI
  13. ↑ Hainan oriental leaf-toed gecko hepacivirus (species) NCBI
  14. ↑ Western African lungfish hepacivirus (species) NCBI
  15. ↑ Wenling moray eel hepacivirus (species) NCBI
  16. ↑ Nanhai dogfish shark hepacivirus (species) NCBI
  17. ↑ Nanhai ghost shark hepacivirus 1 (species) NCBI
  18. ↑ Nanhai ghost shark hepacivirus 2 (species) NCBI
  19. ↑ Wenling shark virus (species) NCBI
  20. ↑ Mang Shi, Xian-Dan Lin, Nikos Vasilakis, Jun-Hua Tian, ​​Ci-Xiu Li, Liang-Jun Chen, Gillian Eastwood, Xiu-Nian Diao, Ming-Hui Chen, Xiao Chen, Xin-Cheng Qin, Steven G. Widen, Thomas G Wood, Robert B Tesh, Jianguo Xu, Edward C Holmes, Yong-Zhen Zhang: Divergent Viruses Discovered in Arthropods and Vertebrates Revise the Evolutionary History of the Flaviviridae and Related Viruses . In: Journal of Virology . 90, No. 2, 2016, pp. 659-69. doi : 10.1128 / JVI.02036-15 . PMID 26491167 . PMC 4702705 (free full text).
  21. ↑ Xiamen sepia Stingray hepacivirus (species) NCBI
  22. ↑ Xiamen guitarfish hepacivirus (species) NCBI