Jack E. Dixon

Jack Edward Dixon (born June 16, 1943 in Nashville , Tennessee ) is an American biochemist at the University of California, San Diego (UCSD).

Dixon earned a BA in Zoology from the University of California, Los Angeles in 1966 and a Ph.D. from the University of California, Santa Barbara in 1971. in chemistry . As a postdoctoral fellow, he worked with the support of the National Science Foundation at the University of California, San Diego , before receiving a first professorship ( Assistant Professor , 1978 Associate Professor ) in Biochemistry at Purdue University . In 1982 he became a full professor there. At the same time, he held professorships at Indiana University (see Indiana University-Purdue University Indianapolis ). In 1991 Dixon moved to the University of Michigan , and in 2003 he was Professor of Pharmacology at the University of California, San Diego. In addition, he holds a professorship at the Salk Institute for Biological Studies and was Vice President and Scientific Director of the Howard Hughes Medical Institute (HHMI) from 2007 to 2013 .

Dixon studies the role of various protein tyrosine phosphatases (PTPases) in reversible phosphorylation . An important virulence factor of Yersinia pestis , the causative agent of the plague, is a PTPase with extremely high enzyme activity . Accordingly, Dixon's work also deals with other virulence factors and their influence on signal transduction . His laboratory was able to show that PTEN dephosphorylates the second messenger PIP3 and thereby activates protein kinase B , which in turn influences the relationship between cell activation and programmed cell death .

Dixon is married to the biochemist Claudia M. Kent.

Awards (selection)

• 1997 member of the American Academy of Arts and Sciences
• 2000 member of the National Academy of Sciences
• 2000 Fellow of the American Association for the Advancement of Science
• 2003 William C. Rose Award from the American Society for Biochemistry and Molecular Biology (ASBMB)
• 2004 Honorary Doctorate from Purdue University
• 2010 member of the American Philosophical Society
• 2012 Foreign member of the Royal Society
• 2013 Honorary Doctorate from Cold Spring Harbor Laboratories
• 2015 Earl and Thressa Stadtman Distinguished Scientist Award

Web links

• Jackson Lab and Jack Dixon at jackdixonlab.com

Individual evidence

1. ↑ Book of Members 1780 – present, Chapter E. (PDF; 477 kB) In: American Academy of Arts and Sciences (amacad.org). Retrieved December 19, 2017 . 
2. ↑ Jack Dixon. In: nasonline.org. Retrieved December 19, 2017 . 
3. ↑ Dixon, Jack E. In: aaas.org. September 28, 2017, accessed December 19, 2017 . 
4. ^ William C. Rose Award. In: asbmb.org. Retrieved December 19, 2017 . 
5. ^ American Philosophical Society - Member History. In: search.amphilsoc.org. Retrieved December 19, 2017 . 
6. ↑ Jack Dixon. In: royalsociety.org. Retrieved December 19, 2017 .