James F. Holland

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James F. Holland

James Frederick Holland (born May 25, 1925 in Morristown , New Jersey - † March 22, 2018 ) was an American doctor ( oncology ) and pioneer in the development of combination chemotherapeutic agents for cancer.

Holland studied at Princeton University with a bachelor's degree in 1944 and medicine from Columbia University with an MD in 1947. He was then employed until 1949 at the Columbia Presbyterian Hospital, was a military doctor in the Korean War (1949 to 1951 as a captain) and was 1951 to 1952 in residency at Francis Delafield Hospital, which had just opened a cancer center. 1952/53 he was an assistant at Columbia University and 1953/54 at the National Cancer Institute (NCI). There he worked with Emil Frei III on combined chemotherapy ( methotrexate , mercaptopurine ) for acute leukemia in children. While still in clinical testing, he took a senior position at the Roswell Park Cancer Institute in Buffalo in 1954 (Chief of Medicine A and Director). The clinical study was expanded to a multi-center study at the NCI, in which Holland in Buffalo was further involved as part of Acute Leucemia Group B , which he headed from 1963 to 1981. He was also a professor at the State University of New York at Buffalo.

In 1973 he became a professor at Mount Sinai Medical Center in New York , where he was director of the Derald H. Ruttenberg Cancer Center from 1985 to 1993.

With Frei and Emil J. Freireich he developed further combination preparations, such as POMP (methotrexate, mercaptopurine, vincristine and prednisone ) against acute lymphoblastic leukemia (ALL) in children. If acute leukemia was incurable at the beginning of their research, they achieved a 10-year survival rate of 50 percent as early as 1975 and later of 80 percent.

He also identified cisplatin as a chemotherapy agent for testicular cancer and doxorubicin for osteosarcoma .

In 2001 he was one of the discoverers of a human breast cancer virus (HMTV) related to the mouse mammary tumor virus .

With Frei he edited the standard work Cancer Medicine , which - edited by other authors - appeared in 2008 in the 9th edition by Wiley.

In 1972 he received the Lasker ~ DeBakey Clinical Medical Research Award and in 1982 the David A. Karnofsky Memorial Award. He was president of the American Association for Cancer Research in 1970/71 and of the American Society of Clinical Oncology from 1976 to 1978 . In 1986 he received the first Return of the Child Award from the Leukemia Society of America.

In 1997 he received an honorary doctorate from the State University of New York at Buffalo . James F. Holland was married to Jimmie C. Holland , who was also an oncologist, until her death in 2017 . They had five children together, and James F. Holland had another daughter.

Web links

Individual evidence

  1. ↑ Pamela Kalte et al: American Men and Women of Science. Thomson Gale, 2004.
  2. ↑ James F. Holland, physician who helped show chemotherapy could treat cancer, dies at 92 , Washington Post , accessed March 27, 2018
  3. ↑ Later CALGB, today Alliance for Clinical Trials in Oncology (ACTION)
  4. ^ EJ Freireich, PH Wiernik, DP Steensma: The leukemias: a half-century of discovery. In: Journal of clinical oncology: official journal of the American Society of Clinical Oncology. Volume 32, number 31, November 2014, pp. 3463–3469, doi: 10.1200 / JCO.2014.57.1034 . PMID 25185093 (Review).
  5. ↑ Teiko Nartey, Heberth Moran, Tania Marin, Kathleen F Arcaro, Douglas L Anderton, Polly Etkind, James F Holland, Stella M Melana, Beatriz GT Pogo: Human Mammary Tumor Virus (HMTV) sequences in human milk. In: Infectious Agents and Cancer. 9 (1), 2014, p. 20.
  6. ↑ SM Melana, I. Nepomnaschy, M. Sakalian, A. Abbott, J. Hasa, JF Holland, BG Pogo: Characterization of viral particles isolated from primary cultures of human breast cancer cells. In: Cancer Research. 67 (18), September 15, 2007, pp. 8960-8965.
  7. ^ Oncology World Mourns the Loss of Jimmie C. Holland, MD, Founder, Field of Psycho-Oncology. In: The ASCO Post. December 26, 2017, accessed December 28, 2017 .
  8. ↑ Beth Fand Incollingo: On the Frontier of Cancer Care: Holland Helped Pioneer Psychosocial Treatment. In: OncLive. July 19, 2013, accessed December 28, 2017 .
personal data
SURNAME Holland, James F.
ALTERNATIVE NAMES Holland, James Frederick (full name)
BRIEF DESCRIPTION American medic
DATE OF BIRTH May 25, 1925
PLACE OF BIRTH Morristown, New Jersey
DATE OF DEATH March 22, 2018