Mevastatin

Structural formula
General
Non-proprietary name	Mevastatin
other names	Compactin; [(1 S , 7 S , 8 S , 8a R ) -8- [2 - [(2 R , 4 R ) -4-hydroxy-6-oxooxan-2-yl] ethyl] -7-methyl-1, 2,3,7,8,8a-hexahydronaphthalen-1-yl] (2 S ) -2-methylbutanoate;
Molecular formula	C 23 H 34 O 5
Brief description	colorless crystals
External identifiers / databases
EC number	700-442-0
ECHA InfoCard	100.131.541
PubChem	64715
ChemSpider	58262
DrugBank	DB06693
Wikidata	Q414407
Drug information
Drug class	Statins
Mechanism of action	HMG-CoA reductase - inhibitor
properties
Molar mass	390.51 g mol −1
Physical state	firmly
Melting point	152 ° C
solubility	easily soluble in methanol and acetone
safety instructions
H and P phrases	H: 317-351-360-362-373-412
	P: 302 + 352-280-273-333 + 313-263
Toxicological data	> 2000 mg kg −1 ( LD 50 , mouse , oral )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Mevastatin , also called compactin, is an active ingredient from the group of statins used to treat disorders of lipid metabolism . It was the first HMG-CoA reductase - inhibitor in the 1970s from Penicillium citrinum was isolated.

Mevastatin is not used in the therapy of lipid metabolism disorders because it has many side effects. However, it is used as the starting compound for the production of other statins such as pravastatin .

Individual evidence

↑ ^a ^b ^c Entry on Compactin. In: Römpp Online . Georg Thieme Verlag, accessed on June 21, 2014.

↑ ^a ^b Registration dossier for (1S, 7S, 8S, 8aR) -8- {2 - [(2R, 4R) -4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl] ethyl} -7-methyl- 1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S) -2-methylbutanoate ( GHS section ) from the European Chemicals Agency (ECHA), accessed on July 7, 2020.

↑ Entry on mevastatin in the ChemIDplus database of the United States National Library of Medicine (NLM), accessed on July 7, 2020.

[Römpp-1] Entry on Compactin. In: Römpp Online . Georg Thieme Verlag, accessed on June 21, 2014.