N -butylbenzenesulfonamide

Structural formula
General
Surname	N-butylbenzenesulfonamide
other names	N -butylbenzenesulfonamide Benzenesulfonic acid butylamide NBBS
Molecular formula	C 10 H 15 NO 2 S
Brief description	colorless liquid with an ammonia-like odor
External identifiers / databases
CAS number 3622-84-2 EC number 222-823-6 ECHA InfoCard 100.020.749 PubChem 19241 ChemSpider 18156 DrugBank DB02055 Wikidata Q14853448
properties
Molar mass	213.29 g mol −1
Physical state	liquid
density	1.15 g cm −3
Melting point	approx. −30 ° C
boiling point	314 ° C
solubility	very sparingly soluble in water (0.45 g l −1 at 20 ° C)
safety instructions
GHS labeling of hazardous substances Caution H and P phrases H: 373-412 P: 262-280-270-273-314-260-501
Toxicological data	2650 mg kg −1 ( LD 50 ,  rat ,  oral ) 2050 mg kg −1 ( LD 50 ,  mouse ,  oral )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

N -Butylbenzenesulfonamide is a chemical compound from the group of sulfonamides .

Occurrence

N -butylbenzenesulfonamide has been found in the bark of Prunus africana and in Pseudomonas sp. detected and found that this substance has high anti-androgenic activity.

Extraction and presentation

N -Butylbenzenesulfonamide can be obtained by reacting n -butylamine with benzenesulfonyl chloride.

properties

N -Butylbenzenesulfonamide is a flammable, hardly inflammable, viscous, colorless liquid with an ammonia- like odor, which is very sparingly soluble in water.

use

N -Butylbenzenesulfonamide is used as a plasticizer for polyamides , cellulose derivatives and PVC.

safety instructions

N -Butylbenzenesulfonamide has neurotoxic effects.

Individual evidence

1. ↑ ^{a b c d e f g h i} Entry on N-Butylbenzenesulfonamide in the GESTIS substance database of the IFA , accessed on August 9, 2018(JavaScript required) .
2. ↑ ^{a b c} Werner Baumann, Thomas Rothardt: Printing chemicals data and facts on environmental protection 2nd, expanded and revised edition . Springer-Verlag, 2013, ISBN 978-3-642-58474-9 , pp. 585 ( limited preview in Google Book search).
3. ↑ Google Patents: DE102005005397B4 - Isolation of N-butylbenzenesulfonamide, synthesis of benzenesulfonamide derivatives and the use of N-butylbenzenesulfonamide and benzenesulfonamide derivatives for the treatment of benign prostatic hyperplasia and / or prostate cancer - Google Patents , accessed on August 9, 2018
4. ↑ National Institutes of Health - US Department of Health and Human Services: Chemical Information Review Document for N-Butylbenzenesulfonamide , Supporting Nomination for Toxicological Evaluation by the National Toxicology Program, October 2010, accessed August 9, 2018
5. ↑ MJ Strong, RM Garruto, AV Wolff, SM Chou, SD Fox, R. Yanagihara: N-Butyl benzenesulfonamide: a neurotoxic plasticizer inducing a spastic myelopathy in rabbits. In: Acta Neuropathologica. 81, 1991, p. 235, doi : 10.1007 / BF00305863 .
6. ↑ CV Rider, KS Janardhan, D. Rao, JP Morrison, CA McPherson, GJ Harry: Evaluation of N-butylbenzenesulfonamide (NBBS) neurotoxicity in Sprague-Dawley male rats following 27-day oral exposure. In: NeuroToxicology. 33, 2012, p. 1528, doi : 10.1016 / j.neuro.2012.07.002 .