Sodium fluorophosphate

Structural formula
General
Surname	Sodium fluorophosphate
other names	Disodium fluorophosphate Sodium monofluorophosphate SODIUM MONOFLUOROPHOSPHATE ( INCI )
Molecular formula	Na 2 PO 3 F
Brief description	white odorless solid
External identifiers / databases
CAS number 10163-15-2 EC number 233-433-0 ECHA InfoCard 100.030.381 PubChem 24266 Wikidata Q3498849
Drug information
ATC code	A01 AA02 A12 CD02
properties
Molar mass	143.95 g mol −1
Physical state	firmly
density	2.6 g cm −3
Melting point	approx. 625 ° C
solubility	Easily soluble in water (250 g l −1 at 20 ° C)
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed GHS labeling of hazardous substances Caution H and P phrases H: 302 P: 301 + 312-330
Toxicological data	502–638 mg kg −1 ( LD 50 ,  rat ,  oral ) 2.1 mg l −1 ( LC 50 ,  rat , inhale 4h )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Sodium fluorophosphate is an inorganic chemical compound from the group of phosphates .

Extraction and presentation

Sodium fluorophosphate can be obtained by reacting sodium metaphosphate with sodium fluoride at 650 ° C.

${\displaystyle \mathrm {NaPO_{3}+NaF\longrightarrow Na_{2}PO_{3}F} }$

properties

Sodium fluorophosphate is a white, odorless solid that is readily soluble in water. Its toxicity is only about 1/3 that of sodium fluoride .

use

Sodium fluorophosphate is used as an active ingredient for fluoridation in toothpastes , tooth varnishes , touch solutions and drinking water . It is also used as a flux for metal melts, ceramic products and for combating mycoses . It is also used in preparations for the treatment of osteoporosis . The caries-reducing effect was discovered in 1950.

Individual evidence

1. ↑ Entry on SODIUM MONOFLUOROPHOSPHATE in the CosIng database of the EU Commission, accessed on December 28, 2019.
2. ↑ ^{a b c d e f g h} Entry on sodium fluorophosphate in the GESTIS substance database of the IFA , accessed on February 27, 2016(JavaScript required) .
3. ↑ ^{a b} Data sheet Sodium fluorophosphate, 95% from Sigma-Aldrich , accessed on February 29, 2016 ( PDF ).
4. ↑ T. Nakajima, B. Žemva, A. Tressaud: Advanced Inorganic Fluorides: Synthesis, Characterization and Applications . Elsevier, 2000, ISBN 978-0-08-052548-8 , pp. 677 ( limited preview in Google Book search).
5. ↑ Entry on sodium fluorophosphate. In: Römpp Online . Georg Thieme Verlag, accessed on February 28, 2016.
6. ↑ Sabine Ellsässer: Body Care and Cosmetics - A textbook for PTA training and advice in pharmacy practice . Springer-Verlag, 2013, ISBN 978-3-662-08181-5 , pp. 309 ( limited preview in Google Book search).
7. ↑ Hasso Scholz, Ulrich Schwabe: Pocket book of drug treatment applied pharmacology . Springer-Verlag, 2006, ISBN 978-3-540-26502-3 , pp. 731 ( limited preview in Google Book search).
8. ^ CIBA Foundation Symposium: Hard Tissue Growth, Repair and Remineralization . John Wiley & Sons, 2009, ISBN 0-470-71761-0 , pp. 49 ( limited preview in Google Book search).