Sodium orthovanadate

Crystal structure
General
Surname	Sodium orthovanadate
other names	Sodium vanadium oxide Trisodium monovanadate
Ratio formula	Na 3 VO 4
Brief description	white solid
External identifiers / databases
CAS number 13721-39-6 16519-60-1 (decahydrate) EC number 237-287-9 ECHA InfoCard 100,033,883 PubChem 61671 Wikidata Q2156566
properties
Molar mass	183.91 g mol −1
Physical state	firmly
density	2.72 g cm −3
Melting point	850-866 ° C
solubility	soluble in water insoluble in ethanol
safety instructions
GHS labeling of hazardous substances Caution H and P phrases H: 302-312-332 P: 280
Toxicological data	330 mg kg −1 ( LD 50 ,  rat ,  oral )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Sodium orthovanadate is an inorganic chemical compound of sodium from the group of vanadates and is one of the well-known sodium vanadates along with sodium metavanadate and sodium pyrovanadate .

Extraction and presentation

Sodium orthovanadate can be obtained by reacting vanadium (V) oxide with a sodium hydroxide solution free of sodium carbonate .

${\displaystyle \mathrm {V_{2}O_{5}+6\ NaOH\longrightarrow 2\ Na_{3}VO_{4}+3\ H_{2}O} }$

It can also be made by fusing vanadium pentoxide with sodium carbonate.

properties

Sodium orthovanadate is a white solid that is soluble in water. It has an orthorhombic crystal structure with the space group Pnmb (space group no. 53, position 2) . The high temperature form has a cubic crystal structure with space group P 2 ₁ 3 (space group no. 198) .

use

Sodium orthovanadate is used to inhibit tyrosine phosphatases , alkaline phosphatases and ATPases . Sodium orthovanadate is usually added to phosphatase inhibitor cocktails in concentrations between 0.1 and 1  mM .

Individual evidence

1. ↑ ^{a b c} Data sheet Sodium orthovanadate, 99.9% (metals basis) from AlfaAesar, accessed on June 18, 2016 ( PDF )(JavaScript required) .
2. ↑ ^{a b c d e f} data sheet Sodium orthovanadate, 99.98% trace metals basis from Sigma-Aldrich , accessed on June 18, 2016 ( PDF ).
3. ^ ^{A b} R. Blachnik: Pocket book for chemists and physicists Volume 3: Elements, inorganic compounds and materials, minerals . Springer-Verlag, 2013, ISBN 978-3-642-58842-6 , pp. 630 ( limited preview in Google Book search).
4. ↑ ^{a b} Entry on sodium vanadate. In: Römpp Online . Georg Thieme Verlag, accessed on June 18, 2016.
5. ↑ Ashok K. Srivastava, Jean-Louis Chiasson: Vanadium Compounds: Biochemical and Therapeutic Applications . Springer Science & Business Media, 2012, ISBN 978-1-4613-1251-2 , pp. 235 ( limited preview in Google Book Search).
6. ↑ appischem.com: Sodium orthovanadate BioChemica: AppliChem - BioChemica.Chemica.Synthesis.Service , accessed on June 18, 2016.