Nucleotide diphosphatase 3
| Ectonucleotide pyrophosphatase / phosphodiesterase family member 3 | ||
|---|---|---|
| other names |
Phosphodiesterase I beta, PD-Ibeta |
|
| Properties of human protein | ||
| Mass / length primary structure | 875 amino acids , 100,124 Da | |
| Identifier | ||
| External IDs | ||
| Enzyme classification | ||
| EC, category | 3.1.4.1 | |
| Orthologue (human) | ||
| Entrez | 5169 | |
| Ensemble | ENSG00000154269 | |
| UniProt | O14638 | |
| Refseq (mRNA) | NM_005021.4 | |
| Refseq (protein) | NP_005012.2 | |
| PubMed search |
5169
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Nucleotide diphosphatase 3 (synonymous NPPase 3 , CD203c ) is an enzyme from the group of pyrophosphatases .
properties
The nucleotide diphosphatase 3 is at the same time a diphosphatase ( EC 3.6.1.9 ) and diesterase ( EC 3.1.4.1 ). It hydrolyzes the bond between two phosphates ( phosphodiester bond ) or between phosphate and sulfate , as does nucleotide diphosphatase 1 . Substrates of nucleotide diphosphatase 3 are e.g. B. NAD + , NADP + , FAD , CoA and UDP-glucose , and some triphosphates such as ATP , GTP , CTP , TTP and UTP and also diadenosine polyphosphates and cAMP . It is formed in the inside of the bile ducts , in the large intestine , in the kidneys , in the prostate and in the uterus , as well as in several cancer cell lines. In addition, NPPase 3 is secreted into the blood serum or the lumen of the respective epithelial cell . The nucleotide diphosphatase 3 can also be found on basophils and mast cells . It's glycosylated .
+ H 2 O + AMP 
The nucleotide diphosphatase 3 is involved in the inhibition of an allergic reaction of basophils.
The nucleotide diphosphatase 3 is used in the basophil activation test for allergies as a marker for the activation of basophils, as does CD63 .
Web links
Individual evidence
- ↑ H. Tsai, K. Takeda: Regulation of allergic inflammation by the ectoenzyme E-NPP3 (CD203c) on basophils and mast cells. In: Seminars in immunopathology. Volume 38, Number 5, September 2016, pp. 571-579, doi : 10.1007 / s00281-016-0564-2 , PMID 27130555 .
- ^ DG Ebo, MM Hagendorens, CH Bridts, LS De Clerck, WJ Stevens: The basophil activation test in immediate drug allergy. In: Acta clinica Belgica. Volume 64, number 2, 2009 Mar-Apr, pp. 129-135, doi : 10.1179 / acb.2009.022 , PMID 19432025 .