Otto-Erich Brodde

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Otto-Erich Brodde (born January 2, 1942 in Dortmund ; † October 13, 2007 ) was a German pharmacologist .

Life

Brodde studied chemistry at the Westphalian Wilhelms University in Münster . In 1972 he was in Munster with a thesis on the synthesis of polysaccharides Dr. rer. nat. PhD . In 1973 he joined Hans-Joachim Schümann as a research assistant at the Pharmacological Institute of the Essen University Hospital . Here he completed his habilitation in pharmacology and toxicology in 1980 and in the same year became head of the biochemical research laboratory of the Clinic for Kidney and Hypertension Diseases at Essen University Hospital. In 1993 he was appointed by the Martin Luther University Halle-Wittenberg to the chair of pharmacology and toxicology of its medical faculty - it was the first appointment of such a chair to a non-medical professional in post-war Germany. In 2002 he returned to Essen University Hospital, where he worked in the Department of Pathophysiology . He retired at the beginning of 2007. He was PhD supervisor of 87 doctoral students.

research

Brodde's main research area was the receptors through which the autonomic nervous system acts on the blood circulation, i.e. the adrenoceptors for the sympathetic and the muscarinic receptors for the parasympathetic . Together with Schümann, he found that there are both α- and β-adrenoceptors in the heart, each with different signal transduction pathways. If this knowledge was initially based on animal experiments, Brodde then turned to more and more studies on humans. The human heart had both β-adrenoceptor subtypes, β 1 and β 2 , both involved in regulating cardiac activity. The closeness to the clinic brought the question of changes in illness and therapy ever closer, such as heart failure , high blood pressure and treatment with catecholamines . Towards the end of his career, Brodde was most interested in the question of how differences in adrenoceptor genes affect living people.

recognition

In 1977 Brodde received the Rottendorf Prize for Pharmacy and Pharmacology, in 1983 the Franz Gross Science Prize of the German Hypertension League , in 1984 the Paul Martini Prize (1984), in 1990 the Walter Clawiter Prize for scientific work on research into hypertension and in 1991 the Fritz-Acker-Preis of the German Society for Cardiology . He was an honorary member of the Japanese Pharmacological Society.

literature

Web links

Individual evidence

  1. ↑ HJ Schümann, M. Endoh and OE Brodde: The time course of the effects of β-adrenoceptor and α-adrenoceptor stimulation by isoprenaline and methoxamine on contractile force and cAMP level of isolated rabbit papillary muscle. In: Naunyn-Schmiedeberg's Archives of Pharmacology 1975; 289: 291-392
  2. ↑ Otto-Erich Brodde and Martin C. Michel: Adrenergic and muscarinic receptors in the human heart. In: Pharmacological Reviews 1999: 51: 651-689
  3. ↑ Otto-Erich Brodde: β 1 -adrenoceptors and β 2 -adrenoceptors in the human heart: properties, function, and alterations in chronic heart failure. In: Pharmacological Reviews 1991: 43: 203-242
  4. ↑ List  ( page no longer available , search in web archives )  Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice. the winner of the Franz-Groß-Wissenschaftspreis, seen July 3, 2012@1@ 2Template: Toter Link / www.hochdruckliga.de  
  5. ^ Prize of the Fritz Acker Foundation on the website of the German Society for Cardiology - Heart and Circulatory Research, as seen on July 3, 2012
  6. ↑ Martin C. Michel: Prof. Otto-Erich Brodde, PhD. In: Autonomic and Autacoid Pharmacology 2008; 28:59, doi: 10.1111 / j.1474-8673.2008.00417.x
personal data
SURNAME Brodde, Otto-Erich
BRIEF DESCRIPTION German pharmacologist
DATE OF BIRTH January 2, 1942
PLACE OF BIRTH Dortmund
DATE OF DEATH October 13, 2007