Hans-Joachim Schümann

Hans-Joachim Schümann (born December 28, 1919 in Stralsund ; † September 5, 1998 in Altenholz ) was a German pharmacologist .

Life

Schümann was the son of a teacher and attended the humanistic high school in his hometown. In 1940 he was given leave of absence from military service to study medicine, which he completed in Cologne , Greifswald and Rostock . After the state examination in 1945 he completed his dissertation with Peter Holtz at the Pharmacological Institute in Rostock to obtain the medical doctorate. He also joined Holtz as an assistant in 1947 and qualified as a lecturer in pharmacology and toxicology with him in 1950 . From 1951 to 1953 he worked at Schering AG in West Berlin . When Holtz moved to Frankfurt am Main in 1953 , he followed him and worked at the Frankfurt Pharmacological Institute until 1964. During this time he did research with Joshua Harold Burn at the Department of Pharmacology at Oxford University , where he mainly worked with Hermann Blaschko .

In 1964 he was appointed full professor at the Essen University Hospital, which is now the University of Duisburg-Essen . The institute was newly founded. He set it up and, despite an appointment at the University of Göttingen, he stayed with it until his retirement in 1985. His Essen students include Athineos Philippu , later professor in Innsbruck , Klaus Starke , later professor in Freiburg im Breisgau , and Otto-Erich Brodde , later professor in Halle (Saale) .

Married since 1949, he had a son and a daughter, both doctors.

Hans-Joachim Schümann

research

Schümann's research focused on the body's own messenger substances dopamine , noradrenaline and adrenaline , the so-called catecholamines . In Frankfurt he showed that in addition to adrenaline, noradrenaline is a hormone of the adrenal medulla and that dopamine occurs in the ganglia of the sympathetic system . The stay in Oxford raised another topic, namely the storage of catecholamines in intracellular vesicles . He found that in addition to catecholamines, the vesicles also contain adenosine triphosphate , usually in a ratio of 4: 1. This common occurrence is a prerequisite for noradrenaline-ATP cotransmission . In Essen, work began on the presynaptic modulation of the release of noradrenaline from postganglionic sympathetic neurons. They led to the discovery of presynaptic receptors for angiotensin II and for noradrenaline itself, the latter of the α ₂ -adrenoceptor type . The mechanism of action of the antihypertensive agent clonidine was also clarified. According to Medline, the most attention in Schümann's work was the discovery and characterization of α-adrenoceptors in the heart muscle , where, in addition to the predominant β-adrenoceptors, they mediate an increase in the force of contraction. He used mechanical, biochemical and electrophysiological measurements as well as the binding of radioligands - with a significant contribution from Otto-Erich Brodde .

Research organization

From 1971 to 1974 Schümann was President of the German Pharmacological Society . For many years he was the advisory editor of Naunyn-Schmiedeberg's archive , the Archives internationales de Pharmacodynamie et de Thérapie ( Gent ) and the Archivos de Farmacologia y Toxicologia (Madrid).

Honors

In 1960 the Royal Society of Medicine (London) elected Schümann as an affiliate member . In 1982 he became an honorary member of the Japanese and in 1985 the German Pharmacological Society .

Individual evidence

1. ↑ Registration of Hans-Joachim Schümann in the Rostock matriculation portal
2. ↑ K. Starke, J. Wagner and HJ Schümann: Adrenergic neuron blockade by clonidine: comparison with guanethidine and local anesthetics. In: Archives internationales de Pharmacodynamie et de Thérapie 1972; 195: 291-308.
3. ↑ HJ Schümann, M. Endoh and J. Wagner: Positive inotropic effects of phenylephrine in the isolated rabbit papillary muscle mediated by α- and β-adrenoceptors. In: Naunyn-Schmiedeberg's Archives of Pharmacology 1974; 284: 133-148. doi : 10.1007 / BF00501118
4. ↑ Klaus Starke: Professor Dr. med. Hans Joachim Schümann on his 65th birthday. In: Drug Research 1984; 34: 1800-1802