Oxybuprocaine

Structural formula
General
Non-proprietary name	Oxybuprocaine
other names	4-Amino-3-butoxybenzoic acid 2-diethylaminoethyl ester ( IUPAC ) ; Benoxinate;
Molecular formula	C 17 H 28 N 2 O 3
External identifiers / databases
PubChem	4633
ChemSpider	4472
DrugBank	DB00892
Wikidata	Q1530958
Drug information
ATC code	S01 HA02 , D04 AB03
Drug class	Local anesthetic
properties
Molar mass	308.42 g · mol -1
Melting point	157-160 ° C (monohydrochloride)
boiling point	215–218 ° C (2.7 hPa)
solubility	Monohydrochloride: soluble in water
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances Hydrochloride; Caution
H and P phrases	H: 315-319-335
	P: 261-305 + 351 + 338
Toxicological data	37 mg kg −1 ( LD 50 , mouse , ip )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Oxybuprocaine is a locally effective anesthetic that is mainly used in ophthalmology (ophthalmology) and in ear, nose and throat medicine (otolaryngology). It is used in medicines as monohydrochloride . The active ingredient was patented by Wander in 1951 .

It is also used for localized inflammation in the throat and throat , often in combination with tyrothricin .

Trade names

Benoxinat (A), Cebesin (CH), Conjuncain (D), Novain (A), Novesine (D, CH), as well as a generic (CH)

Collu-Blache (CH), Fluoresceine-Oxybuprocaine (CH), Flurekain (A), Mebucaine (CH), Thilorbin (D)

↑ ^a ^b ^c ^d ^e Entry on Oxybuprocaine. In: Römpp Online . Georg Thieme Verlag, accessed on July 20, 2019.
↑ ^a ^b Datasheet Benoxinate hydrochloride from Sigma-Aldrich , accessed on April 16, 2011 ( PDF ).
^ Entry on oxybuprocaine in the ChemIDplus database of the United States National Library of Medicine (NLM) .