Pangamic acid

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Structural formula
Structure of pangamic acid
General
Surname Pangamic acid
other names
  • (2 R , 3 S , 4 R , 5 R ) -6- (2-Dimethylamino-acetoxy) -2,3,4,5-tetrahydroxy-hexanoic acid
  • Vitamin B 15
Molecular formula C 10 H 19 NO 8
External identifiers / databases
CAS number 20858-86-0
PubChem 45934203
ChemSpider 32700433
Wikidata Q420405
properties
Molar mass 281.26 g mol −1
safety instructions
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Panamic acid is an ester of gluconic acid and dimethylglycine . It is an intermediate product in the choline metabolism ( choline → betaine → pangamic acid → sarcosine → glycine ).

It was temporarily classified in the group of B vitamins ( vitamin B 15 ), which, however, was not durable because the human body can normally produce sufficient amounts of pangamic acid itself. Therefore, deficiency symptoms are not known. In addition, it is not yet fully understood how it affects the metabolism . According to initial studies in the early 1950s, pangamic acid is said to be bound to cytochrome c oxidase like a cofactor and thus activate the last step in the respiratory chain . Further experimental studies show that pangamic acid can block neuromuscular synapses and α- adrenoceptors and lead to a reduction in blood pressure.

Pumpkin seeds

Pangamic acid or sodium pangamate (the sodium salt of pangamic acid) occurs in apricot kernels , brewer's yeast , unpolished rice - especially in its bran -, in pumpkin seeds , sesame seeds , legumes - especially in the chickpeas - and in whole grains ; In addition, sodium pangamate is marketed under the trade name OYO as a dietary supplement to allegedly improve the cell oxygen supply and correct deficiencies.

In the USA, various combinations of organic and inorganic compounds (such as dimethylglycine , glycine , calcium chloride , ...; also incorrectly referred to as dimethylglycerine) are sold as dietary supplements under the name pangamic acid without a defined composition and therapeutic benefit. The FDA rates these preparations as neither therapeutically effective nor sufficiently safe.

Individual evidence

  1. ↑ Metabolism . Springer-Verlag, 2013, ISBN 978-3-662-30610-9 , pp. 1108 ( limited preview in Google Book search).
  2. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  3. ^ Laszlo Telegdy Kovats, Eva Berndorfer-Kraszner; Agnes Juhasz, Tamas Gabor: Recent data on the structure of pangamic acid (vitamin B 15 ) . Acta Alimentaria Academiae Scientiarum Hungaricae, 1976, 5 (3), 281-288.
  4. ↑ Elson M. Haas: Vitamin B 15 - Pangamic Acid .
  5. ↑ a b c Klaus Pietrzik, Ines Golly, Dieter Loew: Handbook Vitamins: for prophylaxis, advice and therapy . 1st edition. Elsevier, Urban & FischerVerlag, Munich 2008, ISBN 978-3-437-55361-5 , pp. 459-460 .
  6. ↑ Sodium pangamate .
  7. ↑ Ernst Steinegger, Rudolf Hansel: Pharmakognosie . Springer-Verlag, 2013, ISBN 978-3-662-09267-5 , pp. 626 ( limited preview in Google Book search).