Philip P. Green

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Philip Palmer Green (born July 5, 1950 in Durham , North Carolina ) is an American mathematician and geneticist at the University of Washington in Seattle , Washington .

Life

Green earned a bachelor's degree from Harvard University in Cambridge , Massachusetts in 1972 and a Ph.D. in 1976 from the University of California at Berkeley. in mathematics. In 1976 he received a professorship (assistant professor) for mathematics at Columbia University in New York City and was a guest member at the Institute for Advanced Study (IAS) in Princeton , New Jersey in 1977/78 .

Green then turned to biology and worked as a postdoctoral fellow in the Department of Pathology at the University of North Carolina at Chapel Hill before joining Collaborative Research Inc. in Waltham , Massachusetts and the Department of Genetics at Washington University in St. Louis , Missouri , took over. Since 1992 he has been at the University of Washington in Seattle , Washington . There he is professor of genome research as well as bioengineering and computer science . Green is also doing research for the Howard Hughes Medical Institute .

Act

Green developed important computer programs that enabled the systematic and automated analysis of complex genomes . His calculation strategies provided the basis for gene mapping and - sequencing , among others of the human genome ( Human Genome Project ). Important insights into genetic evolution could also be gained. Green realized that only a small part of the genes develop slowly enough to obtain sequences that are sufficiently similar to be recognized as related in phylogenetically distant organisms ( homology ). Green was one of the first to recognize that the number of human genes must be considerably lower than the previously estimated number of 100,000.

Awards (selection)

Fonts (selection)

  • AF Neuwald, P. Green: Detecting patterns in protein sequences. J. Mol. Biol. 1994 239: 698-712.
  • P. Green: Ancient conserved regions in gene sequences. Curr. Opin. Struct. Biol. 1995 4: 404-412.
  • B. Ewing, P. Green: Basecalling of automated sequencer traces using Phred. II. Error probabilities. Genome Res. 1998 8: 186-194.
  • P. Green, E. Koonin: Genomes and evolution: glimpses of an emerging synthesis. Curr. Opin. Genet. Dev. 1999 9: 621-623.
  • B. Ewing, P. Green: Analysis of expressed sequence tags indicates 35,000 human genes. Nature Genetics 2000 25: 232-234.

Web links

Individual evidence

  1. Philip P. Green PhD at the Gairdner Foundation (gairdner.org); Retrieved December 15, 2012
  2. Green, Philip. In: aaas.org. February 24, 2017, accessed April 2, 2018 .