Propyl gallate

Structural formula
General
Surname	Propyl gallate
other names	3,4,5-trihydroxybenzoic acid propyl ester; Propyl 3,4,5-trihydroxybenzoate; Gallic acid propyl ester; E 310 ; PROPYL GALLATE ( INCI ) ;
Molecular formula	C 10 H 12 O 5
Brief description	gray odorless solid
External identifiers / databases
EC number	204-498-2
ECHA InfoCard	100.004.090
PubChem	4947
ChemSpider	4778
DrugBank	DB12450
Wikidata	Q608726
properties
Molar mass	212.20 g mol −1
Physical state	firmly
density	1.21 g cm −3
Melting point	147-149 ° C
solubility	heavy in water (3.5 g l −1 at 25 ° C); soluble in ethanol, diethyl ether and oils;
safety instructions
GHS hazard labeling from Regulation (EC) No. 1272/2008 (CLP) , expanded if necessary Caution
H and P phrases	H: 302-317
	P: 280-302 + 352
Toxicological data	2100 mg kg −1 ( LD 50 , rat , oral )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Propyl gallate ( propyl 3,4,5-trihydroxybenzoate ) is a chemical compound from the group of gallates and an ester of gallic acid.

Extraction and presentation

Propyl gallate can be obtained by reacting gallic acid with propanol .

properties

Propyl gallate is a flammable, gray, odorless solid that is sparingly soluble in water.

use

Propyl gallate is used as an antioxidant in pesticides, the food industry and in cosmetics. It is also used as an aid in fluorescence microscopy to reduce the fading of fluorescent samples such as rhodamine and fluorescein .

Individual evidence

↑ Entry on E 310: Propyl gallate in the European database on food additives, accessed on June 28, 2020.
↑ Entry on PROPYL GALLATE in the CosIng database of the EU Commission, accessed on July 6, 2020.
↑ ^a ^b ^c ^d ^e ^f ^g ^h Entry on propyl 3,4,5-trihydroxybenzoate in the GESTIS substance database of the IFA , accessed on January 8, 2018(JavaScript required) .
↑ unknown: Final Report on the Amended Safety Assessment of Propyl Gallate. In: International Journal of Toxicology. 26, 2007, p. 89, doi: 10.1080 / 10915810701663176 .
↑ Entry on Propyl 3,4,5-trihydroxybenzoate in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on August 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .
↑ ^a ^b Entry on propyl gallate in the Hazardous Substances Data Bank , accessed September 19, 2015.
↑ EPA: Inert Reassessment - Propyl Gallate (CAS Reg. No. 121-79-9) , accessed September 19, 2015.
↑ Data sheet Propyl gallate, antioxidant, ≥98.0% (HPLC) from Sigma-Aldrich , accessed on September 19, 2015 ( PDF ).

[E-Nummer310-1] Entry on E 310: Propyl gallate in the European database on food additives, accessed on June 28, 2020.

[CosIng-2] Entry on PROPYL GALLATE in the CosIng database of the EU Commission, accessed on July 6, 2020.

[GESTIS-3] ↑ ^a ^b ^c ^d ^e ^f ^g ^h Entry on propyl 3,4,5-trihydroxybenzoate in the GESTIS substance database of the IFA , accessed on January 8, 2018(JavaScript required) .

[DOI10.1080/10915810701663176-4] unknown: Final Report on the Amended Safety Assessment of Propyl Gallate. In: International Journal of Toxicology. 26, 2007, p. 89, doi: 10.1080 / 10915810701663176 .

[CLP_100.004.090-5] Entry on Propyl 3,4,5-trihydroxybenzoate in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on August 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .

[HSDB-6] Entry on propyl gallate in the Hazardous Substances Data Bank , accessed September 19, 2015.

[epa.gov-7] EPA: Inert Reassessment - Propyl Gallate (CAS Reg. No. 121-79-9) , accessed September 19, 2015.

[Sigma-8] Data sheet Propyl gallate, antioxidant, ≥98.0% (HPLC) from Sigma-Aldrich , accessed on September 19, 2015 ( PDF ).