The genus Rubulavirus within the virus family Paramyxoviridae comprises various mammalian RNA virus species. The name of the genus comes from the old name for mumps ( Rubula infans ), the causative agent of which is the mumps virus , the type species of the genus.
The virions (virus particles) of the genus Rubulavirus are about 150 nm in diameter, pleomorphic and almost spherical in shape. The irregularity results from the lack of a solid inner, spherical structure. Instead of an icosahedral capsid , as is characteristic of paramyxoviruses, they have a helical, coiled capsid with a diameter of 18 nm. A virus protein HN with hemagglutinin and neuraminidase activity is stored in the viral envelope of the rubula viruses . The single-stranded RNA genome has negative polarity and includes the six reading frames N (nucleocapsid protein), P / V ( phosphoprotein / virion protein), M ( matrix protein ), F ( fusion protein ), HN ( envelope protein ), L ( large ), which also exist in other paramyxoviruses protein , RNA polymerase ). In addition, the genome (similar to the Pneumoviridae family ) contains a reading frame for a small, hydrophobic protein SH ( small hydrophobic ). Encoding the P / V protein mRNA subject in the genus Rubulavirus an RNA editing and is also smaller than that of the other genera in the family. The genome is about 15 to 16 kilobases in length .
RA Lamb et al .: Genus Rubulavirus . In: CM Fauquet, MA Mayo et al .: Eighth Report of the International Committee on Taxonomy of Viruses . London, San Diego, 2005 ISBN 0-12-249951-4 pp. 659f
SK Samal: Paramyxoviruses of Animals. In: Brian WJ Mahy and Marc H. van Regenmortel (eds.): Encyclopedia of Virology , 3rd edition, San Diego 2008 (Volume 4) ISBN 978-0-12-373935-3 p. 40ff
