Ryanodine

Structural formula
General
Surname	Ryanodine
other names	6- (1 α , 5a β , 8a β , 9-pentahydroxy-7 β -isopropyl-2 β , 5 β , 8 β -trimethylperhydro-8b α , 9-epoxy-5,8-ethanocyclopenta- [1,2- b ] indenyl) pyrrole-2-carboxylate
Molecular formula	C 25 H 35 NO 9
Brief description	white solid
External identifiers / databases
EC number	239-732-2
ECHA InfoCard	100.036.105
PubChem	441753
Wikidata	Q424726
properties
Molar mass	493.55 g mol −1
Physical state	firmly
Melting point	219-220 ° C
solubility	easily soluble in water
safety instructions
H and P phrases	H: 302 + 312-410
	P: 273-302 + 352
Toxicological data	650 mg kg −1 ( LD 50 , mouse , oral )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

The diterpene derivative ryanodine is a whitish light-sensitive substance that is soluble in methanol and ethanol . It is an ingredient of the Ryania speciosa plant from South America and has been used as an insecticide for around 200 years .

Even small amounts of ryanodine are toxic to humans. It binds to the ryanodine receptors named after him , which are mainly found in the striated skeletal and cardiac muscles and causes calcium to flow out of the sarcoplasmic reticulum . In the case of intoxication , continuous muscle contractions occur .

Individual evidence

↑ ^a ^b ^c ^d ^e Entry on ryanodine in the GESTIS substance database of the IFA , accessed on January 9, 2019(JavaScript required) .
↑ Entry on 6- (1α, 5aβ, 8aβ, 9-pentahydroxy-7β-isopropyl-2β, 5β, 8β-trimethylperhydro-8bα, 9-epoxy-5,8-ethanocyclopenta [1,2-b] indenyl) pyrrole- 2-carboxylate Template: Linktext-Check / Escaped in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .
^ Entry on ryanodine in the ChemIDplus database of the United States National Library of Medicine (NLM) .
↑ Tocris: ryanodine Cat. No. 1329 , accessed July 25, 2015.
↑ Lexicon of Biology: Ryanodine - Lexicon of Biology , accessed on July 25, 2015.
↑ ^a ^b Rudolf Hänsel, Otto Sticher: Pharmakognosie - Phytopharmazie . Springer-Verlag, 2007, ISBN 978-3-540-34281-6 , pp. 1468 ( limited preview in Google Book Search).

[GESTIS-1] Entry on ryanodine in the GESTIS substance database of the IFA , accessed on January 9, 2019(JavaScript required) .

[CLP_100.036.105-2] Entry on 6- (1α, 5aβ, 8aβ, 9-pentahydroxy-7β-isopropyl-2β, 5β, 8β-trimethylperhydro-8bα, 9-epoxy-5,8-ethanocyclopenta [1,2-b] indenyl) pyrrole- 2-carboxylate Template: Linktext-Check / Escaped in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .

[ChemIDplus-3] Entry on ryanodine in the ChemIDplus database of the United States National Library of Medicine (NLM) .

[Tocris-4] Tocris: ryanodine Cat. No. 1329 , accessed July 25, 2015.

[Spektrum-5] Lexicon of Biology: Ryanodine - Lexicon of Biology , accessed on July 25, 2015.

[Phytopharmazie-6] Rudolf Hänsel, Otto Sticher: Pharmakognosie - Phytopharmazie . Springer-Verlag, 2007, ISBN 978-3-540-34281-6 , pp. 1468 ( limited preview in Google Book Search).