Sidney A. Bernhard

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Sidney A. Bernhard (1927–1988)

Sidney A. Bernhard (* 1927 ; † 1988 ) was an American chemist and professor of chemistry at the University of Oregon in Eugene .

Career

Bernhard grew up in Brooklyn , studied chemistry at Brooklyn College and received his "Masters degree" from Pennsylvania State University in 1949 . Work on his doctorate (1949-1951) he carried out under Louis P. Hammett at Columbia University . As a “National Research Council Fellow” he worked with Linus Pauling at the California Institute of Technology (1951–1953), then he spent almost a year in England at Cambridge University . After returning to the United States, he worked as a chemist in the Division of Physical Biochemistry at the Naval Medical Research Institute (Bethesda) (1954–1958), later as head of physical chemistry (1958–1961). In 1961 he became a member of the Chemistry Department at the newly established Institute of Molecular Biology at the University of Oregon.

Bernhard started his career as a physical chemist, then he expanded his interest to include topics in physical biochemistry and molecular biology : enzyme kinetics , reaction mechanisms and regulation. This includes pioneering work on fast reactions using the then new stopped-flow method . He was particularly interested in oligomeric enzymes such as acetylcholinesterase (AcChE), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), alcohol dehydrogenase (ADH), and the ATPases . The first evidence for the "half-of-the-sites reactivity" in GAPDH goes back to Bernhard, which became a possible explanation for cooperative bonding phenomena . Later work focused on the direct transfer mechanisms of metabolites between dehydrogenases, glycolytic enzymes and tryptophan synthases. This expanded knowledge of multienzyme complexes to include important dynamic aspects.

literature

  1. SA Bernhard, (1968) The Structure and Function of Enzymes, p. 324, WA Benjamin
  2. B. Matthews, SA Bernhard (1973) Annu. Rev. Biophys. Bioeng. 2, 257-317
  3. F. Seydoux, 0. P. Malhotra, SA Bernhard (1974) Crit. Rev. Biochem. 2, 227-257
  4. DK Srivastava, SA Bernhard (1987) Annu. Rev. Biophys. Chem. 16, 175-204

Web links

Individual evidence

  1. ^ Biographical data, publications and academic family tree of Sidney A. Bernhard at academictree.org, accessed on January 6, 2018.
personal data
SURNAME Bernhard, Sidney A.
BRIEF DESCRIPTION American chemist
DATE OF BIRTH 1927
DATE OF DEATH 1988