Silver sulfadiazine

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Structural formula
Structure of silver sulfadiazine
General
Surname Silver sulfadiazine
other names
  • Sulfadiazine silver
  • 4-Amino- N - (pyrimidin-2-yl) benzenesulfonamide silver salt
Molecular formula C 10 H 9 AgN 4 O 2 S
External identifiers / databases
CAS number 22199-08-2
EC number 244-834-5
ECHA InfoCard 100.040.743
PubChem 441244
ChemSpider 390017
DrugBank DB05245
Wikidata Q420984
Drug information
ATC code

D06 BA01

Drug class

Sulfonamide

properties
Molar mass 357.14 g mol −1
Physical state

firmly

Melting point

285 ° C

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
07 - Warning

Caution

H and P phrases H: 315-319-335
P: 261-305 + 351 + 338
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Silver sulfadiazine is the silver salt of sulfadiazine (previously a so-called standard sulfonamide) and has an antibacterial effect against a large number of germs. Silver sulfadiazine is locally ( topically applied), mainly in superficial, fresh wounds (eg. As by burns second and third degree, large abrasions).

Silver sulfadiazine cream is used during the healing phase or until a skin graft. It prevents the growth of a broad spectrum of bacteria and yeasts on the injured skin due to its antibacterial effect as a sulfonamide , but also due to the oligodynamic effect of the silver ion . Silver sulfadiazine is poorly soluble in water. Silver binds to proteins from the wound exudate , with sulfadiazine being released from the sulfadiazine silver compound and a small part (up to 10%) being absorbed.

A longer application can lead to the formation of a local argyrosis due to the silver content .

See also

Trade names

Monopreparations

InfectoFlam (D), Flammazine (D, A, CH)

Combination preparations

Individual evidence

  1. ↑ a b c Data sheet Silver (I) sulfadiazine from Sigma-Aldrich , accessed on April 23, 2011 ( PDF ).
  2. ↑ Karl Wurm, AM Walter: Infectious Diseases. In: Ludwig Heilmeyer (ed.): Textbook of internal medicine. Springer-Verlag, Berlin / Göttingen / Heidelberg 1955; 2nd edition, ibid. 1961, pp. 9-223, here: pp. 43-46.
  3. ^ Carr, HS. et al. (1973): Silver sulfadiazine: in vitro antibacterial activity . In: Antimicrobial Agents and Chemotherapy . 4 (5); 585-7; PMID 4791493 ; PDF (free full text access).
  4. ↑ Specialist information Flammazine Creme, as of June 2008.
  5. ↑ Chaby, G. et al. (2005): Topical silver sulfadiazine-induced acute renal failure . In: Annales de Dermatologie et de Vénéréologie . 132 (11 Pt 1); 891-3; PMID 16327720 .
  6. ↑ Trop, M. et al. (2006): Silver-coated dressing acticoat caused raised liver enzymes and argyria-like symptoms in burn patient . In: The Journal of Trauma . 60 (3); 648-52; PMID 16531870 .
  7. ↑ Fisher, NM. et al. (2003): Scar-localized argyria secondary to silver sulfadiazine cream . In: J Am Acad Dermatol. 49 (4); 730-2; PMID 14512929 .