Stefan Jentsch

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Stefan Jentsch (born May 29, 1955 in Berlin ; † October 29, 2016 ) was a German cell biologist . From 1998 he was director at the Max Planck Institute for Biochemistry in Martinsried. The molecular medicine specialist Thomas Jentsch is the older brother of Stefan Jentsch.

Life

Jentsch studied biology at the Free University of Berlin , where he also graduated in 1979 and obtained his doctorate in 1983. For his doctorate he did research at the Max Planck Institute for Molecular Genetics in Thomas Trautner's group .

After completing his doctorate, he went to the Massachusetts Institute of Technology as a postdoctoral fellow in Alexander Varshavsky's laboratory . From 1988 he was head of an independent junior research group at the Friedrich Miescher Laboratory of the Max Planck Society in Tübingen , and in 1993 he was appointed to a professorship for cell biology at the Center for Molecular Biology (ZMBH) at Heidelberg University. In 1998 he accepted a position as director at the Max Planck Institute for Biochemistry in Martinsried. From 1998 Stefan Jentsch was a member of the German Academy of Sciences Leopoldina .

plant

Stefan Jentsch mainly researched the function of the ubiquitin system and ubiquitin-like systems. In particular, he is studying their role in protein breakdown and DNA repair . The modification of proteins with the small protein ubiquitin was originally described as a marker for protein degradation. However, Stefan Jentsch was able to show that ubiquitin also plays a decisive role in genome stability and DNA repair. His research was particularly relevant from a medical point of view, as damaged DNA can cause various diseases such as cancer.

Prizes and awards

Publications (selection)

  • GI Karras, S. Jentsch: The RAD6 DNA damage tolerance pathway operates uncoupled from the replication fork and is functional beyond S-phase. In: Cell. Volume 141, 2010, pp. 255-267.
  • C. Pohl, S. Jentsch: Midbody ring disposal by autophagy is a post-abscission event of cytokinesis. In: Nat. Cell Biol. Vol. 11, 2009, pp. 65-70.
  • C. Pohl, S. Jentsch: Final stages of cytokinesis and midbody ring formation are controlled by BRUCE. In: Cell. Volume 132, 2008, pp. 832-845.
  • H. Richly, M. Rape, S. Braun, S. Rumpf, C. Hoege, S. Jentsch: A series of ubiquitin-binding factors connects CDC48 / p97 to substrate multi-ubiquitylation and proteasomal targeting. In: Cell. Volume 120, 2005, pp. 73-84.
  • B. Pfander, G.-L. Moldovan, M. Sacher, C. Hoege, S. Jentsch: SUMO-modified PCNA recruits Srs2 to prevent recombination during S-phase. In: Nature . Volume 436, 2005, pp. 428-433.
  • C. Hoege, B. Pfander, G.-L. Moldovan, G. Pyrowolakis, S. Jentsch: RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. In: Nature. Volume 419, 2002, pp. 135-141.
  • M. Rape, T. Hoppe, I. Gorr, M. Kalocay, H. Richly, S. Jentsch: Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48UFD1 / NPL4, a ubiquitin-selective chaperone. In: Cell. Volume 107, 2001, pp. 667-677.
  • T. Hoppe, K. Matuschewski, M. Rape, S. Schlenker, HD Ulrich, S. Jentsch: Activation of a membrane-bound transcription factor by regulated ubiquitin / proteasome-dependent processing. In: Cell. Volume 102, 2000, pp. 557-586.
  • M. Koegl, T. Hoppe, S. Schlenker, HD Ulrich, TU Mayer, S. Jentsch: A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. In: Cell. Volume 96, 1999, pp. 635-644.
  • D. Liakopoulos, G. Doenges, K. Matuschewski, S. Jentsch: A novel protein modification pathway related to the ubiquitin system. In: EMBO J . Volume 17, 1998, pp. 2208-2214.
  • T. Sommer, S. Jentsch: A protein translocation defect linked to ubiquitin-conjugation at the endoplasmic reticulum. In: Nature. Volume 365, 1993, pp. 176-179.
  • W. Seufert, S. Jentsch: Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins. In: EMBO J. Volume 9, 1990, pp. 543-550.
  • S. Jentsch, JP McGrath, A. Varshavsky : The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme. In: Nature. Volume 329, 1987, pp. 131-134.
  • Restriction and modification in B [acillus] subtilis: characterization of different chromosomal and phage-coded systems. [Berlin] 1982, DNB 840153384 (dissertation FU Berlin 1983, 82 pages).

literature

  • Max Planck Society (ed.): Manual of the Scientific Members of the Max Planck Society. Munich 2006
  • Franz-Ulrich Hartl : Stefan Jentsch: May 29, 1955 - October 29, 2016 (obituary for Jentsch), in: Annual Report of the Max Planck Society 2016, Beileger, page 5.

Web links

Individual evidence

  1. ↑ Stefan Jentsch, 1955–2016 . Max Planck Institute for Biochemistry , November 2, 2016, accessed November 3, 2016.
  2. ^ Stefan Jentsch (1955-2016). In: cell.com. Retrieved December 21, 2016 .
  3. ↑ Member entry by Prof. Dr. Stefan Jentsch at the German Academy of Sciences Leopoldina , accessed on July 7, 2016.
  4. ^ Membership directory: Stefan Jentsch. Academia Europaea, accessed June 30, 2017 .
  5. ↑ Anke Lischeid: Prof. Dr. Stefan Jentsch posthumously receives Otto Warburg Medal 2017. Society for Biochemistry and Molecular Biology, press release from April 6, 2017 at Informationsdienst Wissenschaft (idw-online.de), accessed on April 6, 2017.
personal data
SURNAME Jentsch, Stefan
BRIEF DESCRIPTION German cell biologist
DATE OF BIRTH May 29, 1955
PLACE OF BIRTH Berlin
DATE OF DEATH October 29, 2016