Tubocurarine

Structural formula
General
Non-proprietary name	Tubocurarine
Molecular formula	C 37 H 41 N 2 O 6
Brief description	yellowish solid
External identifiers / databases
PubChem	6000
ChemSpider	5778
DrugBank	DB01199
Wikidata	Q421268
Drug information
ATC code	M03 AA02
properties
Molar mass	609.73 g · mol -1
Physical state	firmly
Melting point	268 ° C
solubility	soluble in water
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances danger
H and P phrases	H: 301
	P: 301 + 310
Toxicological data	150 mg kg −1 ( LD 50 , mouse , oral )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Tubocurarine is a neurotoxin . As the main component of Tubocurare, it is one of the arrow poisons , which are collectively referred to as curare .

Occurrence

Tubocurarine is found in Chondrodendron tomentosum and other plants of the genus.

Mode of action

Tubocurarine competitively occupies the nicotinic acetylcholine receptors of the postsynaptic membrane. The ligand- controlled sodium ion channels are blocked , with no depolarization being triggered. Tubocurarine paralyzes the striated muscles of the musculoskeletal system and is known as a non-depolarizing muscle relaxant .

pharmacy

Tubocurarine is used as a pharmaceutical active ingredient as chloride hydrochloride pentahydrate. It was used in the preparation Intocostrin in 1942 to relax muscles during anesthesia.

Individual evidence

↑ ^a ^b ^c Entry on tubocurarine dichloride in the GESTIS substance database of the IFA , accessed on February 6, 2017(JavaScript required) .
↑ ^a ^b Data sheet (+) - Tubocurarine chloride pentahydrate from Sigma-Aldrich , accessed on April 25, 2011 ( PDF ).
↑ Tubocurarine data sheet from Acros, accessed on February 26, 2010.
↑ Wink, Michael; Ben-Erik van Wyk; Coralie Wink, Handbook of Poisonous and Psychoactive Plants. Scientific publishing company, Stuttgart, 2008.
↑ External identifiers or database links for tubocurarine chloride hydrochloride pentahydrate : CAS number: 6989-98-6, EC number: 615-023-7, ECHA InfoCard: 100.108.489 , GESTIS substance database : 531432 , PubChem : 23422 , ChemSpider : 21902 , Wikidata : Q27271261 .
^ Entry on Tubocurarine in the DrugBank of the University of Alberta , accessed December 9, 2018.
↑ Erich Kirchner: Preliminary remark. In: Erich Kirchner, Wolfgang Seitz (Hrsg.): Clinic of muscle relaxation. 50 years after Griffith and Johnson. Steinkopff, Darmstadt 1994; Reprint ibid 2012, ISBN 978-3-642-95978-3 , p. 1.

[GESTIS-1] Entry on tubocurarine dichloride in the GESTIS substance database of the IFA , accessed on February 6, 2017(JavaScript required) .

[sigma-2] Data sheet (+) - Tubocurarine chloride pentahydrate from Sigma-Aldrich , accessed on April 25, 2011 ( PDF ).

[3] Tubocurarine data sheet from Acros, accessed on February 26, 2010.

[4] Wink, Michael; Ben-Erik van Wyk; Coralie Wink, Handbook of Poisonous and Psychoactive Plants. Scientific publishing company, Stuttgart, 2008.

[5] External identifiers or database links for tubocurarine chloride hydrochloride pentahydrate : CAS number: 6989-98-6, EC number: 615-023-7, ECHA InfoCard: 100.108.489 , GESTIS substance database : 531432 , PubChem : 23422 , ChemSpider : 21902 , Wikidata : Q27271261 .

[6] Entry on Tubocurarine in the DrugBank of the University of Alberta , accessed December 9, 2018.

[7] Erich Kirchner: Preliminary remark. In: Erich Kirchner, Wolfgang Seitz (Hrsg.): Clinic of muscle relaxation. 50 years after Griffith and Johnson. Steinkopff, Darmstadt 1994; Reprint ibid 2012, ISBN 978-3-642-95978-3 , p. 1.