GABA transporter type 1: Difference between revisions
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Revision as of 20:10, 21 October 2014
GABA transporter 1 (GAT-1) also known as sodium- and chloride-dependent GABA transporter 1 is a protein that in humans is encoded by the SLC6A1 gene.[1][2]
Function
GAT-1 a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft.[3]
Interactions
SLC6A1 has been shown to interact with STX1A.[4][5][6]
See also
References
- ^ Huang F, Shi LJ, Heng HH, Fei J, Guo LH (February 1996). "Assignment of the human GABA transporter gene (GABATHG) locus to chromosome 3p24-p25". Genomics. 29 (1): 302–4. doi:10.1006/geno.1995.1253. PMID 8530094.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1".
- ^ Hirunsatit R, George ED, Lipska BK, Elwafi HM, Sander L, Yrigollen CM, Gelernter J, Grigorenko EL, Lappalainen J, Mane S, Nairn AC, Kleinman JE, Simen AA (January 2009). "Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity". Pharmacogenet. Genomics. 19 (1): 53–65. doi:10.1097/FPC.0b013e328318b21a. PMC 2791799. PMID 19077666.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Beckman, M L; Bernstein E M; Quick M W (August 1998). "Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A". J. Neurosci. 18 (16). UNITED STATES: 6103–12. ISSN 0270-6474. PMID 9698305.
{{cite journal}}: Cite has empty unknown parameters:|laysummary=,|laydate=, and|laysource=(help) - ^ Quick, Michael W (April 2002). "Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner". Proc. Natl. Acad. Sci. U.S.A. 99 (8). United States: 5686–91. doi:10.1073/pnas.082712899. ISSN 0027-8424. PMC 122832. PMID 11960023.
{{cite journal}}: Cite has empty unknown parameters:|laydate=,|laysummary=, and|laysource=(help) - ^ Deken, S L; Beckman M L; Boos L; Quick M W (October 2000). "Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A". Nat. Neurosci. 3 (10). UNITED STATES: 998–1003. doi:10.1038/79939. ISSN 1097-6256. PMID 11017172.
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Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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