GABA transporter type 1

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GABA transporter 1 (GAT1) also known as sodium- and chloride-dependent GABA transporter 1 is a protein that in humans is encoded by the SLC6A1 gene.[1][2]

Function

GAT1 a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft.[3] The stoichiometry of this transporter is 2 Na+ and 1 Cl- in.

Interactions

SLC6A1 has been shown to interact with STX1A.[4][5][6]

See also

References

  1. ^ Huang F, Shi LJ, Heng HH, Fei J, Guo LH (February 1996). "Assignment of the human GABA transporter gene (GABATHG) locus to chromosome 3p24-p25". Genomics. 29 (1): 302–4. doi:10.1006/geno.1995.1253. PMID 8530094.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ "Entrez Gene: SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1".
  3. ^ Hirunsatit R, George ED, Lipska BK, Elwafi HM, Sander L, Yrigollen CM, Gelernter J, Grigorenko EL, Lappalainen J, Mane S, Nairn AC, Kleinman JE, Simen AA (January 2009). "Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity". Pharmacogenet. Genomics. 19 (1): 53–65. doi:10.1097/FPC.0b013e328318b21a. PMC 2791799. PMID 19077666.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^ Beckman ML, Bernstein EM, Quick MW (August 1998). "Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A". J. Neurosci. 18 (16): 6103–12. PMID 9698305.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  5. ^ Quick MW (April 2002). "Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner". Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5686–91. doi:10.1073/pnas.082712899. PMC 122832. PMID 11960023.
  6. ^ Deken SL, Beckman ML, Boos L, Quick MW (October 2000). "Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A". Nat. Neurosci. 3 (10): 998–1003. doi:10.1038/79939. PMID 11017172.{{cite journal}}: CS1 maint: multiple names: authors list (link)

Further reading

  • Nelson H, Mandiyan S, Nelson N (1990). "Cloning of the human brain GABA transporter". FEBS Lett. 269 (1): 181–4. doi:10.1016/0014-5793(90)81149-I. PMID 2387399.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Bennett ER, Kanner BI (1997). "The membrane topology of GAT-1, a (Na+ + Cl-)-coupled gamma-aminobutyric acid transporter from rat brain". J. Biol. Chem. 272 (2): 1203–10. doi:10.1074/jbc.272.2.1203. PMID 8995422.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  • Bismuth Y, Kavanaugh MP, Kanner BI (1997). "Tyrosine 140 of the gamma-aminobutyric acid transporter GAT-1 plays a critical role in neurotransmitter recognition". J. Biol. Chem. 272 (26): 16096–102. doi:10.1074/jbc.272.26.16096. PMID 9195904.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  • DeFelipe J, González-Albo MC (1998). "Chandelier cell axons are immunoreactive for GAT-1 in the human neocortex". NeuroReport. 9 (3): 467–70. doi:10.1097/00001756-199802160-00020. PMID 9512391.
  • Conti F, Melone M, De Biasi S, Minelli A, Brecha NC, Ducati A (1998). "Neuronal and glial localization of GAT-1, a high-affinity gamma-aminobutyric acid plasma membrane transporter, in human cerebral cortex: with a note on its distribution in monkey cortex". J. Comp. Neurol. 396 (1): 51–63. doi:10.1002/(SICI)1096-9861(19980622)396:1<51::AID-CNE5>3.0.CO;2-H. PMID 9623887.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Beckman ML, Bernstein EM, Quick MW (1998). "Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A". J. Neurosci. 18 (16): 6103–12. PMID 9698305.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Augood SJ, Waldvogel HJ, Münkle MC, Faull RL, Emson PC (1999). "Localization of calcium-binding proteins and GABA transporter (GAT-1) messenger RNA in the human subthalamic nucleus". Neuroscience. 88 (2): 521–34. doi:10.1016/S0306-4522(98)00226-7. PMID 10197772.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Ong WY, Yeo TT, Balcar VJ, Garey LJ (2000). "A light and electron microscopic study of GAT-1-positive cells in the cerebral cortex of man and monkey". J. Neurocytol. 27 (10): 719–30. doi:10.1023/A:1006946717065. PMID 10640187.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Deken SL, Beckman ML, Boos L, Quick MW (2000). "Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A". Nat. Neurosci. 3 (10): 998–1003. doi:10.1038/79939. PMID 11017172.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Whitworth TL, Quick MW (2001). "Substrate-induced regulation of gamma-aminobutyric acid transporter trafficking requires tyrosine phosphorylation". J. Biol. Chem. 276 (46): 42932–7. doi:10.1074/jbc.M107638200. PMID 11555659.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  • Hachiya Y, Takashima S (2002). "Development of GABAergic neurons and their transporter in human temporal cortex". Pediatr. Neurol. 25 (5): 390–6. doi:10.1016/S0887-8994(01)00348-4. PMID 11744314.
  • Quick MW (2002). "Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner". Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5686–91. doi:10.1073/pnas.082712899. PMC 122832. PMID 11960023.
  • Kanner BI (2003). "Transmembrane domain I of the gamma-aminobutyric acid transporter GAT-1 plays a crucial role in the transition between cation leak and transport modes". J. Biol. Chem. 278 (6): 3705–12. doi:10.1074/jbc.M210525200. PMID 12446715.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  • Zomot E, Kanner BI (2003). "The interaction of the gamma-aminobutyric acid transporter GAT-1 with the neurotransmitter is selectively impaired by sulfhydryl modification of a conformationally sensitive cysteine residue engineered into extracellular loop IV". J. Biol. Chem. 278 (44): 42950–8. doi:10.1074/jbc.M209307200. PMID 12925537.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  • Zhou Y, Bennett ER, Kanner BI (2004). "The aqueous accessibility in the external half of transmembrane domain I of the GABA transporter GAT-1 Is modulated by its ligands". J. Biol. Chem. 279 (14): 13800–8. doi:10.1074/jbc.M311579200. PMID 14744863.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  • Hu JH, Ma YH, Jiang J, Yang N, Duan SH, Jiang ZH, Mei ZT, Fei J, Guo LH (2004). "Cognitive impairment in mice over-expressing gamma-aminobutyric acid transporter 1 (GAT1)". NeuroReport. 15 (1): 9–12. doi:10.1097/00001756-200401190-00003. PMID 15106822.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Korkhov VM, Farhan H, Freissmuth M, Sitte HH (2005). "Oligomerization of the {gamma}-aminobutyric acid transporter-1 is driven by an interplay of polar and hydrophobic interactions in transmembrane helix II". J. Biol. Chem. 279 (53): 55728–36. doi:10.1074/jbc.M409449200. PMID 15496410.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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