4-dimethylaminophenol

Structural formula
General
Non-proprietary name	4-dimethylaminophenol
other names	N , N -dimethyl p -hydroxyanilin; 4-DMAP (ambiguous);
Molecular formula	C 8 H 11 NO
External identifiers / databases
EC number	210-604-8
ECHA InfoCard	100.009.642
PubChem	22174
ChemSpider	20816
Wikidata	Q229950
Drug information
ATC code	V03 AB27
Drug class	Antidote
properties
Molar mass	137.18 g mol −1
Melting point	76-77 ° C
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances Caution
H and P phrases	H: 302-315-319-335
	P: ?
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

4-Dimethylaminophenol (4-DMAP) is an antidote (antidote) in the event of poisoning by cyanides , hydrogen cyanide , nitriles and hydrogen sulfide . The principle of action is based on the formation of methemoglobin to bind free cyanide ions. Hemolysis can occur as a side effect .

The administration of 4-DMAP is only one step to counteract poisoning by cyanide ions. The administration of sodium thiosulfate or hydroxycobalamin is unavoidable.

The administration of 4-DMAP is contraindicated due to its mode of action in smoke gas intoxication, as mixed intoxication with carbon monoxide must always be suspected.

4-DMAP was no longer available on the German market from 2014 to 2017 due to a production changeover. Alternative products therefore had to be used.

Overdose

Methylene blue can be administered as an antidote to an overdose of 4-DMAP (dimethylaminophenol) .

Likelihood of confusion

Due to the identical abbreviations ( 4-DMAP ), it may be confused with 4- (dimethylamino) pyridine , which is not an antidote for hydrocyanic acid poisoning.

Individual evidence

^ E. Bamberger, P. Leyden: Further contributions to the knowledge of Dimethylanilinoxyds. In: Chem. Ber. 34, 1901, pp. 12-26, doi: 10.1002 / cber.19010340106 .
↑ Template: CL Inventory / not harmonized There is not yet a harmonized classification for this substance . A labeling of 4- (dimethylamino) phenol in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on January 16, 2020, is reproduced from a self-classification by the distributor .
↑ Entry on 4-DMAP. In: Römpp Online . Georg Thieme Verlag, accessed on November 14, 2017.
↑ T. Zilker et al.: Smoke inhalation intoxication. In: The emergency doctor. 26, 2010, pp. 95-102.
↑ Brief information on the 6th Jour Fixe on the subject of "Delivery and supply bottlenecks" from March 22, 2018

[1] E. Bamberger, P. Leyden: Further contributions to the knowledge of Dimethylanilinoxyds. In: Chem. Ber. 34, 1901, pp. 12-26, doi: 10.1002 / cber.19010340106 .

[2] Template: CL Inventory / not harmonized There is not yet a harmonized classification for this substance . A labeling of 4- (dimethylamino) phenol in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on January 16, 2020, is reproduced from a self-classification by the distributor .

[Roempp-3] Entry on 4-DMAP. In: Römpp Online . Georg Thieme Verlag, accessed on November 14, 2017.

[4] T. Zilker et al.: Smoke inhalation intoxication. In: The emergency doctor. 26, 2010, pp. 95-102.

[5] Brief information on the 6th Jour Fixe on the subject of "Delivery and supply bottlenecks" from March 22, 2018