Alphenal

Structural formula
General
Non-proprietary name	Alphenal
other names	5-phenyl-5-prop-2-enyl-1,3-diazinan-2,4,6-trione; Phenallymal; Prophetic;
Molecular formula	C 13 H 12 N 2 O 3
External identifiers / databases
EC number	204-089-9
ECHA InfoCard	100.003.718
PubChem	8274
ChemSpider	7975
Wikidata	Q414954
Drug information
Drug class	sedative
properties
Molar mass	244.25 g · mol -1
Physical state	firmly
Melting point	156.5 ° C
solubility	Slightly soluble in water (1.720 g l −1 at 25 ° C), benzene , DMSO ; easily soluble in ethanol , diethyl ether ;
safety instructions
H and P phrases	H: 225-301-311-331-370
	P: 210-260-280-301 + 310-311
Toxicological data	265 mg kg −1 ( LD 50 , mouse , ip ) ; 280 mg kg −1 ( LD 50 , mouse , oral ) ; 233 mg kg −1 ( LD 50 , rat , ip ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Alphenal is a drug from the group of barbiturates that was previously used as a sedative and sleep aid . Structurally it is a derivative of barbituric acid . It was developed in the 1960s and has primarily anticonvulsant effects, which is why it was occasionally used to treat epilepsy or convulsions . There are currently no more drugs based on Alphenal on the market and it is no longer approved in Germany.

Individual evidence

^ ^A ^b David R. Lide: CRC Handbook of Chemistry and Physics . 87th edition, 2006, CRC Press, ISBN 978-0-8493-0487-3 , chap. 3, p. 424.
↑ ^a ^b ^c ^d Entry on Alphenal in the ChemIDplus database of the United States National Library of Medicine (NLM) .
↑ ^a ^b Datasheet Alphenal at Sigma-Aldrich , accessed on May 12, 2011 ( PDF ).
↑ ^a ^b Farmaco, Edizione Scientifica. 17: 390 (1962).
^ Svensk Farmaceutisk Tidskrift. (Swedish Journal of Pharmacy.) Vol. 56, p. 31, 1952.
^ WHO : WHO Expert Committee on Drug Dependence. (PDF; 2.3 MB) 32nd Report, Geneva, 1987, p. 42.

[crc-1] A ^b David R. Lide: CRC Handbook of Chemistry and Physics . 87th edition, 2006, CRC Press, ISBN 978-0-8493-0487-3 , chap. 3, p. 424.

[chemid-2] Entry on Alphenal in the ChemIDplus database of the United States National Library of Medicine (NLM) .

[Sigma-3] Datasheet Alphenal at Sigma-Aldrich , accessed on May 12, 2011 ( PDF ).

[farmaco-4] Farmaco, Edizione Scientifica. 17: 390 (1962).

[5] Svensk Farmaceutisk Tidskrift. (Swedish Journal of Pharmacy.) Vol. 56, p. 31, 1952.

[who-6] WHO : WHO Expert Committee on Drug Dependence. (PDF; 2.3 MB) 32nd Report, Geneva, 1987, p. 42.