Amyl metacresol

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Structural formula
Structural formula of amyl metacresol
General
Surname Amyl metacresol
other names

5-methyl-2-pentylphenol

Molecular formula C 12 H 18 O
External identifiers / databases
CAS number 1300-94-3
EC number 215-094-0
ECHA InfoCard 100,013,722
PubChem 14759
DrugBank DB13908
Wikidata Q1946346
Drug information
ATC code

R02 AA20

Drug class

antiseptic

properties
Molar mass 178.27 g mol −1
Physical state

liquid

Melting point

24 ° C

boiling point

138 ° C

solubility
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
07 - Warning

Caution

H and P phrases H: 302
P: 301 + 312
Toxicological data

300–2000 mg kg −1 ( LD 50 ,  rat ,  oral )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Amylmetacresol (AMC) is a chemical compound that is derived from phenol as well as from toluene or from m -cresol . It is used together with 2,4-dichlorobenzyl alcohol as an antiseptic to treat infections in the mouth and throat. It comes in the form of lozenges, a solution or a spray.

effect

Amylmetacresol has a disinfectant effect against viruses, bacteria, fungi and yeasts. An analgesic effect has also been shown in clinical studies.

literature

  • Amin Ebneshahidi, Masood Mohseni: Strepsils® Tablets Reduce Sore Throat and Hoarseness After Tracheal Intubation . In: Anesthesia & Analgesia . tape 111 , no. 4 , February 2010, p. 892-894 , doi : 10.1213 / ANE.0b013e3181d00c60 , PMID 20142339 .
  • Weckmann G, Hauptmann-Voss A, Baumeister SE, Klötzer C, Chenot JF: Efficacy of AMC / DCBA lozenges for sore throat: A systematic review and meta-analysis . In: Int J Clin Pract . 71, No. 10, 2017, pp. 1742-1241. PMID 28869700 .

Individual evidence

  1. ↑ a b c d e data sheet amylmetacresol (PDF) at EDQM , accessed on July 11, 2018.
  2. ↑ a b c David R. Lide (Ed.): CRC Handbook of Chemistry and Physics . 89th edition. (Internet version: 2009), CRC Press / Taylor and Francis, Boca Raton, FL, Physical Constants of Organic Compounds, pp. 3-366.
  3. ^ D. McNally, M. Simpson, C. Morris, A. Shephard, M. Goulder: Rapid relief of acute sore throat with AMC / DCBA throat lozenges: randomized controlled trial . In: International Journal of Clinical Practice . tape 64 , no. 2 , 2010, p. 194-207 , doi : 10.1111 / j.1742-1241.2009.02230.x , PMID 19849767 .